Reference : Subclinical cerebellar impairment in the common types of migraine: a three-dimensiona...
Scientific journals : Article
Human health sciences : Neurology
Social & behavioral sciences, psychology : Neurosciences & behavior
Subclinical cerebellar impairment in the common types of migraine: a three-dimensional analysis of reaching movements.
Sandor, P. S. [> > > >]
Mascia, A. [> > > >]
SEIDEL, Laurence mailto [> >]
De Pasqua, Victor [Centre Hospitalier Universitaire de Liège - CHU > > Neurologie CHR >]
Schoenen, Jean mailto [Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Neuro-anatomie >]
Annals of Neurology
Wiley Liss, Inc.
Yes (verified by ORBi)
New York
[en] Adult ; Arm/physiopathology ; Cerebellar Diseases/physiopathology ; Female ; Humans ; Male ; Migraine Disorders/physiopathology ; Movement/physiology
[en] Mutations in the CACNA1A gene can cause familial hemiplegic migraine (FHM) and/or cerebellar ataxia CACNA1A codes for the alpha1 subunit of P/Q-Ca2+ channels and is highly expressed in the cerebellum. Using a pointing paradigm and infrared optoelectronic tracking system, we found subclinical hypermetria and other subtle cerebellar signs in the common forms of migraine. These were more pronounced in migraine with than without aura. Whether this reflects involvement of Ca2+ channel genes in the common types of migraine needs to be investigated by genetic analyses.

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