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Article (Scientific journals)
Human Anti-Alpha-Galactosyl Igg Reduces the Lung Colonization by Murine Mo4 Cells
Castronovo, Vincenzo; Foidart, Jean-Michel; Li Vecchi, M. et al.
1987In Invasion and Metastasis, 7 (6), p. 325-45
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Abstract :
[en] The lung colonization of MO4 cells, a highly malignant murine cell line, is strongly reduced in syngeneic C3H/He mice by a prior incubation with anti-alpha-galactosyl antibody (alpha-Gal Ab), a natural IgG antibody present in high titers in all normal human sera and specifically recognizing Gal alpha(1----3) structures (alpha-D-galactopyranosyl; alpha-D-Galp). The protective effect is due to a binding of alpha-Gal Ab to alpha-D-Galp end groups of MO4 cells, inducing both an increase in their sequestration into the liver and the spleen and a decrease in their sequestration into the lung. The F(ab')2 fragments of this antibody also exhibit a protective effect by inhibiting the homing of MO4 cells into the lung, without modifying their accumulation into the spleen and the liver. Since both the antibody and the alpha-galactosidase pretreatments of MO4 cells block their subsequent attachment to murine laminin in vitro, we suggest that, in this model, the lung colonization may be dependent on the alpha-D-Galp end groups exposed on the surface of MO4 cells.
Disciplines :
Oncology
Biochemistry, biophysics & molecular biology
Author, co-author :
Castronovo, Vincenzo ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biologie générale et cellulaire
Foidart, Jean-Michel ;  Université de Liège - ULiège > Département des sciences cliniques > Gynécologie - Obstétrique
Li Vecchi, M.
Foidart, J. B.
Bracke, M.
Mareel, M.
Mahieu, P.
Language :
English
Title :
Human Anti-Alpha-Galactosyl Igg Reduces the Lung Colonization by Murine Mo4 Cells
Publication date :
1987
Journal title :
Invasion and Metastasis
ISSN :
0251-1789
Publisher :
Karger, Switzerland
Volume :
7
Issue :
6
Pages :
325-45
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 28 September 2009

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