Cytogenetic Changes in Hepatocarcinomas from Rats Treated with Chronic Exposure to Diethylnitrosamine

Herens, Christian; Alvarez Gonzalez, Maria-Luz; Barbason, Hervé

doi:10.1016/0165-4608(92)90232-W

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Cytogenetic Changes in Hepatocarcinomas from Rats Treated with Chronic Exposure to Diethylnitrosamine

Herens, Christian; Alvarez Gonzalez, Maria-Luz; Barbason, Hervé

1992 • In Cancer Genetics and Cytogenetics, 60 (1), p. 45-52

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https://hdl.handle.net/2268/23884

DOI
10.1016/0165-4608(92)90232-W

PubMed
1591706

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Abstract :

[en] Cytogenetic analysis of rat hepatocarcinomas obtained after diethylnitrosamine (DEN) exposure showed a wide variety of numerical and structural chromosomal changes: 53 of 86 hepatocellular carcinomas showed at least one recurrent chromosomal aberration. Some of these recurrent changes occurred in several tumors. Chromosomes 1, 3, 11, and 12 were abnormal in more than 30% of the carcinomas; chromosomes 2, 4, 5, and 10 were abnormal in 10%. Moreover, chromosomes 1 and 10 were generally lost or deleted and chromosome 3, 4, and 11 were very often gained. The most frequent anomaly was loss of chromosome 1 which was observed in 35% of the tetraploid cell populations. The occurrence in several tumors of recurrent chromosomal rearrangements as well as various repeated aneuploidies strongly suggests that these anomalies are implicated in the process of rat hepatocarcinogenesis induced by DEN treatment.

Disciplines :

Genetics & genetic processes

Author, co-author :

Herens, Christian ; Centre Hospitalier Universitaire de Liège - CHU > PLAN COS

Alvarez Gonzalez, Maria-Luz ; Université de Liège - ULiège > Département des sciences cliniques > Labo de biologie des tumeurs et du développement

Barbason, Hervé ; Université de Liège - ULiège > Relations académiques et scientifiques (Médecine)

Language :

English

Title :

Cytogenetic Changes in Hepatocarcinomas from Rats Treated with Chronic Exposure to Diethylnitrosamine

Publication date :

May 1992

Journal title :

Cancer Genetics and Cytogenetics

ISSN :

0165-4608

eISSN :

1873-4456

Publisher :

Elsevier Science

Volume :

Issue :

Pages :

45-52

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 25 September 2009

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