Application of dual-cyclodextrin systems in capillary electrophoresis enantioseparations

Servais, Anne-Catherine; Fillet, Marianne

doi:10.1007/978-1-4939-9438-0_19

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Application of dual-cyclodextrin systems in capillary electrophoresis enantioseparations

Servais, Anne-Catherine; Fillet, Marianne

2019 • In Methods in Molecular biology: Chiral Separations

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https://hdl.handle.net/2268/237544

DOI
10.1007/978-1-4939-9438-0_19

PubMed
31069744

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Keywords :

Acidic compounds; Capillary electrophoresis; Dual-cyclodextrin system; Neutral compounds

Abstract :

[en] The enantioseparation of acidic and neutral compounds can be successfully achieved in capillary electrophoresis (CE) using dual-cyclodextrin (CD) systems. This chapter describes how to separate the enantiomers of acidic or neutral substances using dual-CD systems made up of a negatively charged CD derivative, i.e., sulfobutyl-β-CD or carboxymethyl-β-CD, in combination with a neutral one, namely heptakis(2,3,6-tri-O-methyl)-β-CD. An acidic compound (carprofen) and a weakly acidic drug (pentobarbital) were selected as model compounds. © Springer Science+Business Media, LLC, part of Springer Nature 2019.

Disciplines :

Pharmacy, pharmacology & toxicology

Author, co-author :

Servais, Anne-Catherine ; Université de Liège - ULiège > Département de pharmacie > Analyse des médicaments

Fillet, Marianne ; Université de Liège - ULiège > Département de pharmacie > Analyse des médicaments

Language :

English

Title :

Application of dual-cyclodextrin systems in capillary electrophoresis enantioseparations

Publication date :

2019

Main work title :

Methods in Molecular biology: Chiral Separations

Publisher :

Humana Press Inc.

Pages :

357-364

Available on ORBi :

since 26 June 2019

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