Enantioseparations in nonaqueous capillary electrophoresis using charged cyclodextrins

Servais, Anne-Catherine; Fillet, Marianne

doi:10.1007/978-1-4939-9438-0_21

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Enantioseparations in nonaqueous capillary electrophoresis using charged cyclodextrins

Servais, Anne-Catherine; Fillet, Marianne

2019 • In Methods in Molecular biology: Chiral Separations

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https://hdl.handle.net/2268/237543

DOI
10.1007/978-1-4939-9438-0_21

PubMed
31069746

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Keywords :

Acidic compounds; Basic compounds; Nonaqueous capillary electrophoresis; Single-isomer charged β-cyclodextrin derivatives

Abstract :

[en] The enantioseparation of acidic and basic compounds can be successfully achieved in nonaqueous capillary electrophoresis (NACE) using single-isomer charged β-cyclodextrin (β-CD) derivatives of opposite charge to that of the analytes. This chapter describes how to separate the enantiomers of three basic substances selected as model compounds, i.e., alprenolol, bupranolol, and terbutaline, using the negatively charged heptakis(2,3-di-O-acetyl-6-O-sulfo)-β-CD (HDAS-β-CD). The enantiomers of three acidic drugs (tiaprofenic acid, suprofen, and flurbiprofen) are resolved using a monosubstituted amino β-CD derivative, namely 6-monodeoxy-6-mono(3-hydroxy)propylamino-β-CD (PA-β-CD). © Springer Science+Business Media, LLC, part of Springer Nature 2019.

Research Center/Unit :

CIRM - Centre Interdisciplinaire de Recherche sur le Médicament - ULiège

Disciplines :

Pharmacy, pharmacology & toxicology

Author, co-author :

Servais, Anne-Catherine ; Université de Liège - ULiège > Département de pharmacie > Analyse des médicaments

Fillet, Marianne ; Université de Liège - ULiège > Département de pharmacie > Analyse des médicaments

Language :

English

Title :

Enantioseparations in nonaqueous capillary electrophoresis using charged cyclodextrins

Publication date :

2019

Main work title :

Methods in Molecular biology: Chiral Separations

Publisher :

Humana Press Inc.

Pages :

373-381

Available on ORBi :

since 26 June 2019

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