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A new natural hGH variant--17.5 kd--produced by alternative splicing. An additional consensus sequence which might play a role in branchpoint selection
Lecomte, C. M.; Renard, A.; Martial, Joseph
1987In Nucleic Acids Research, 15 (16), p. 6331-48
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Keywords :
Base Sequence; Chorionic Gonadotropin/*genetics; DNA/genetics; Genes; Genes, Regulator; Humans; Molecular Weight; Pituitary Neoplasms/analysis; *RNA Splicing; RNA, Neoplasm/genetics/isolation & purification; Recombinant Proteins/genetics
Abstract :
[en] From a human pituitary cDNA library, we have cloned 3 distinct human growth hormone (hGH) cDNAs, coding respectively for the 22 K hGH, the 20 K variant, and a yet unknown 17.5 K variant. S1 mapping analysis using human pituitary RNA confirms the existence of at least four distinct hGH mRNAs originating from alternative acceptor sites at the second intron of the primary transcript. We have analysed the hGH gene sequence to explain the high frequency of alternative splicings which occur only at this location. In this study we propose CTTGNNPyPyPy as an additional consensus sequence guiding the selection of the branched nucleotide.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Lecomte, C. M.
Renard, A.
Martial, Joseph ;  Université de Liège - ULiège > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire
Language :
English
Title :
A new natural hGH variant--17.5 kd--produced by alternative splicing. An additional consensus sequence which might play a role in branchpoint selection
Publication date :
1987
Journal title :
Nucleic Acids Research
ISSN :
0305-1048
eISSN :
1362-4962
Publisher :
Oxford University Press, Oxford, United Kingdom
Volume :
15
Issue :
16
Pages :
6331-48
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 24 September 2009

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