Reference : Cytological and cytochemical analysis of the effects of cis-dichlorodiamino platinum ...
Scientific journals : Article
Life sciences : Anatomy (cytology, histology, embryology...) & physiology
http://hdl.handle.net/2268/23605
Cytological and cytochemical analysis of the effects of cis-dichlorodiamino platinum (II) on chick fibroblasts cultivated in vitro.
English
Heinen, Ernst mailto [Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Histologie humaine >]
Bassleer, R. [> > > >]
1976
Chemotherapy
S. Karger
22
3-4
253-61
Yes (verified by ORBi)
International
0009-3157
1421-9794
[en] Animals ; Cell Division/drug effects ; Cell Nucleolus/drug effects/ultrastructure ; Chick Embryo ; Chromatin/drug effects ; Cisplatin/toxicity ; Cytoplasm/drug effects ; DNA/biosynthesis ; Fibroblasts/drug effects/metabolism/ultrastructure ; Mitosis/drug effects ; RNA/biosynthesis
[en] Chick embryo fibroblasts cultivated in vitro and treated with cis-dichlorodiamino platinum (II) have been analysed by cytological and cytochemical methods. Morphological alterations (in the nucleoli, in the chromatin and in the cytoplasm), inhibition of DNA and RNA syntheses and of cell multiplication have been noted. Under some conditions, cells are blocked just before entering into mitosis (G2 block) and can become polyploid. A high degree of cell degeneration has also been observed.
http://hdl.handle.net/2268/23605
also: http://hdl.handle.net/2268/23190

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