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Article (Scientific journals)
Cytological and cytochemical analysis of the effects of cis-dichlorodiamino platinum (II) on chick fibroblasts cultivated in vitro.
Heinen, Ernst; Bassleer, Roger
1976In Chemotherapy, 22 (3-4), p. 253-61
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Keywords :
Animals; Cell Division/drug effects; Cell Nucleolus/drug effects/ultrastructure; Chick Embryo; Chromatin/drug effects; Cisplatin/toxicity; Cytoplasm/drug effects; DNA/biosynthesis; Fibroblasts/drug effects/metabolism/ultrastructure; Mitosis/drug effects; RNA/biosynthesis
Abstract :
[en] Chick embryo fibroblasts cultivated in vitro and treated with cis-dichlorodiamino platinum (II) have been analysed by cytological and cytochemical methods. Morphological alterations (in the nucleoli, in the chromatin and in the cytoplasm), inhibition of DNA and RNA syntheses and of cell multiplication have been noted. Under some conditions, cells are blocked just before entering into mitosis (G2 block) and can become polyploid. A high degree of cell degeneration has also been observed.
Disciplines :
Anatomy (cytology, histology, embryology...) & physiology
Author, co-author :
Heinen, Ernst ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Histologie humaine
Bassleer, Roger ;  Université de Liège - ULiège > Relations académiques et scientifiques (Médecine)
Language :
English
Title :
Cytological and cytochemical analysis of the effects of cis-dichlorodiamino platinum (II) on chick fibroblasts cultivated in vitro.
Publication date :
1976
Journal title :
Chemotherapy
ISSN :
0009-3157
eISSN :
1421-9794
Publisher :
S. Karger
Volume :
22
Issue :
3-4
Pages :
253-61
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 24 September 2009

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