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Correlation between song learning and perineuronal nets development in song control system nuclei of juvenile canaries
Cornez, Gilles; Collignon, Clémentine; Müller, Wendt et al.
2018Neuroscience 2018
 

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Abstract :
[en] Perineuronal nets (PNN) are aggregations of extracellular matrix components surrounding the soma of specific neurons, mainly GABAergic interneurons expressing the calcium binding protein parvalbumin (PV+). In mammals, the development of PNN limits synaptogenesis around PV+ neurons and PNNs have been identified as a marker of the end of sensitive periods for brain plasticity in several neuronal systems. In songbirds, vocal learning requires exposure to conspecific vocalizations by male tutors during a sensitive period. This is followed by a sensorimotor period when birds progressively match their vocalizations with the memorized tutor’s song until the fully mature song is crystallized. In a closed-ended learner, the zebra finch, PNN expression in select song nuclei is higher in males than in females and higher in adults than in juvenile males. The timing of PNN appearance in the developing zebra finch brain correlates with the timing of sensitive periods for song learning. We also showed that PNN are more densely expressed in the song control system of zebra finches than in two open-ended learners, the European starling and the canary and that testosterone (T) induces song crystallization in early spring and increases the number of PNN in castrated canaries. Together these data suggest that PNN might regulate the end of the sensitive period(s) for vocal learning during ontogeny. To elucidate this question further, we quantified PNN expression at critical time points during the first year of life in canaries and correlated these data with their song development. Brains were collected from groups of males (n=6-8/group) at time points corresponding to specific vocal developmental stages: first spring (subsong), summer (early plastic song), fall (plastic song), winter (ongoing song crystallization), and second spring (fully crystallized song/adults). In winter, one additional group received T implants to test whether this accelerates PNN development and song crystallization. The number of PNN reached their maximum in the fall in HVC but only in the winter in RA and Area X. In the group treated with T there was no further enhancement of PNN expression over what was observed in untreated birds at the same age. Total song duration and song developmental score only reached their maximum in the spring and were enhanced by T in the winter. Other song characteristics such as the energy or bandwidth were already at the adult levels during the winter. Most of these song measurements correlated with the number of PNN in the song nuclei suggesting that PNN contribute to song crystallization that starts in the winter and is completed at the onset of spring.
Disciplines :
Animal psychology, ethology & psychobiology
Author, co-author :
Cornez, Gilles ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biologie de la différenciation sexuelle du cerveau
Collignon, Clémentine ;  Université de Liège - ULiège > Master sc. psycho., à fin.
Müller, Wendt
Ball, Grégory
Cornil, Charlotte  ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biologie de la différenciation sexuelle du cerveau
Balthazart, Jacques  ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques
Language :
English
Title :
Correlation between song learning and perineuronal nets development in song control system nuclei of juvenile canaries
Publication date :
05 November 2018
Event name :
Neuroscience 2018
Event organizer :
Society for Neuroscience
Event place :
San Diego, United States - California
Event date :
du 3 au 7 novembre 2018
Audience :
International
Available on ORBi :
since 26 April 2019

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