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MEMBRANE ESTROGEN RECEPTOR ALPHA PARTICIPATES IN THE ORGANIZATION OF THE BRAIN BY PERINATAL ESTROGENS
Cornil, Charlotte; Khbouz, Badr; Court, Lucas et al.
2019Symposium on Sex Differences
 

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Abstract :
[en] Estrogens exert pleiotropic effects on multiple physiological and behavioral responses. Male and female sexual behaviors in rodents constitute some of the best characterized responses activated by estrogens in adulthood and largely depend on estrogen receptor alpha (ERα). Evidence exists that nucleus- and membrane-initiated estrogen signaling cooperate to orchestrate the activation of these behaviors both short- and long-term. However questions remain regarding the mechanism(s) and receptor(s) involved in the early brain programming during development to organize the circuits underlying sexually differentiated endpoints. Taking advantage of a mouse model harboring a mutation of the ERα palmitoylation site which invalidates membrane ER signaling (mERα), this study investigated the role of mERα on the expression of male and female sexual behavior and neuronal populations that differ between sexes. The results revealed no effect of genotype on the expression of female sexual behavior while male sexual behavior was significantly reduced but not impaired in males homozygous for the mutation. Similarly, the number of kisspeptin- (Kp-ir) and calbindin-immunoreactive (Cb-ir) neurons in the anteroventral periventricular nucleus (AVPv) and the sexually-dimorphic nucleus of the preoptic area (SDN-POA) respectively were not different between genotypes in females, while homozygous males showed an increased number of Kp-ir and a decreased number of Cb-ir neurons compared to their wild-type littermates thus leading to an intermediate phenotype between females and wild-type males. Importantly, females treated with estrogens between post-natal day 0 and 5 exhibited the same neurochemical phenotype as their corresponding genotype in males. Together, these data provide evidence that mERα is involved in the perinatal programming of the male brain.
Research center :
Giga-Neurosciences - ULiège
Disciplines :
Neurosciences & behavior
Author, co-author :
Cornil, Charlotte  ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biologie de la différenciation sexuelle du cerveau
Khbouz, Badr ;  Université de Liège - ULiège > Département des sciences cliniques > Néphrologie
Court, Lucas ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biologie de la différenciation sexuelle du cerveau
Tazaiux, Mélanie
Corona, Rebeca
Arnal, Jean-François
Lenfant, Françoise
Language :
English
Title :
MEMBRANE ESTROGEN RECEPTOR ALPHA PARTICIPATES IN THE ORGANIZATION OF THE BRAIN BY PERINATAL ESTROGENS
Publication date :
21 May 2019
Event name :
Symposium on Sex Differences
Event place :
Erice, Italy
Event date :
May 20-25 2019
Audience :
International
Funders :
Fédération Wallonie Bruxelles. Fonds de la Recherche Scientifique - F.R.S.-FNRS
Available on ORBi :
since 24 April 2019

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