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Immunomodulatory properties of cyclic hexapeptide oxytocin antagonists
Geenen, Vincent; Martens, Henri; Robert, Françoise et al.
1992In Thymus, 20, p. 217-226
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Abstract :
[en] A pharmacological manipulation of cryptocrine cell-to-cell signaling was tested by the investigation of the immunomodulatory properties of novel cyclic hexapeptide oxytocin (OT) antagonists (MSD Research Laboratories). The compounds were found to significantly inhibit the productions of IL-1ß and IL-6 elicited by anti-CD3 treatment oh human whole blood cells cultures (WBC). Cytokine productions were more significantly reduced by OT antagonists in WBC derived from female volunteers than in those obtained from male donors, suggesting an influence of sex steroids on the expression of NHP receptors by immune cells. These observations support the concept of novel immunomodulating approaches through immune-specific neuropeptide antagonists, as well as the pharmacological value of such strategies in selective immunotherapy.
Disciplines :
Immunology & infectious disease
Author, co-author :
Geenen, Vincent ;  Université de Liège - ULiège > Centre d'immunologie - Embryologie
Martens, Henri ;  Université de Liège - ULiège > Centre d'immunologie
Robert, Françoise
Vrindts-Gevaert, Yvonne
De Groote, Donat
Franchimont, Paul
Language :
English
Title :
Immunomodulatory properties of cyclic hexapeptide oxytocin antagonists
Publication date :
1992
Journal title :
Thymus
ISSN :
0165-6090
Publisher :
Kluwer Academic Publishers, Dordrecht, Netherlands
Volume :
20
Pages :
217-226
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
Available on ORBi :
since 23 September 2009

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