Emperipolesis of lymphoid cells by human follicular dendritic cells in vitro.

Tsunoda, R.; Nakayama, M.; Heinen, Ernst; Miyake, K.; Suzuki, K.; Sugai, N.; Kojima, M.

doi:10.1007/BF02899667

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Emperipolesis of lymphoid cells by human follicular dendritic cells in vitro.

Tsunoda, R.; Nakayama, M.; Heinen, Ernst et al.

1992 • In Virchows Archiv. B: Cell Pathology, 62 (2), p. 69-78

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https://hdl.handle.net/2268/23275

DOI
10.1007/BF02899667

PubMed
1355323

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Keywords :

Antigens, Differentiation/metabolism; Cell Adhesion/physiology; Dendritic Cells/immunology/physiology/ultrastructure; Humans; Immunoenzyme Techniques; Lymphocytes/physiology/ultrastructure; Microscopy; Microscopy, Phase-Contrast; Palatine Tonsil/cytology

Abstract :

[en] Isolated follicular dendritic cells (FDCs) showed true and pseudoemperipolesis of fresh tonsillar lymphocytes, even after long-term (50-day) cultivation. Emperipolesis by FDCs was not restricted by allotype specificity, nor was it inhibited by the addition of antibodies against MHC-I & II antigens. Follicular dendritic cells predominantly engulfed B-cells; monocytes and macrophages were not found between FDC cytoplasmic extensions. When highly purified T-cell populations were added to FDC cultures emperipolesis of T-cells occurred, particularly those of the CD4-positive phenotype. Mitoses appeared within 6 h in the emperipolesed lymphocytes and, after an additional 18 h, some lymphocytes exhibited apoptosis.

Disciplines :

Anatomy (cytology, histology, embryology...) & physiology

Author, co-author :

Tsunoda, R.

Nakayama, M.

Heinen, Ernst ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Histologie humaine

Miyake, K.

Suzuki, K.

Sugai, N.

Kojima, M.

Language :

English

Title :

Emperipolesis of lymphoid cells by human follicular dendritic cells in vitro.

Publication date :

1992

Journal title :

Virchows Archiv. B: Cell Pathology

ISSN :

0340-6075

Publisher :

Springer Verlag, Berlin, Germany

Volume :

Issue :

Pages :

69-78

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 22 September 2009

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Bibliography

Andrew P., Boyd R.L., Shortman K. (1985) The limited immunocompetence of thymocytes within murine thymic nurse cells. European Journal of Immunology 15:1043-1048.
Braun M., Heinen E., Cormann N., Kinet-Denoël C., Simar L.J. (1987) Influence of immunoglobulin isotypes and lymphoid cell phenotype on the transfer of immune complexes to FDC. Cell Immunol 107:99-106.
Cormann N., Lesage F., Heinen E., Schaaf-Lafontaine N., Kinet-Denoël C., Simar L.J. (1986) Isolation of follicular dendritic cells from human tonsils and adenoids. V. Effect on lymphocyte proliferation and differentiation. Immunol Lett 14:29-35.
Cormann N., Heinen E., Kinet-Denoël C., Tsunoda R., Simar L.J. (1988) Isolation of follicular dendritic cells from human tonsils and adenoids. In vitro culture. Adv Exp Med Biol 237:171-175.
Defresne M.P., Rongy A.M., Greimers R., Boniver J. (1986) Cellular aspects of radiation leukemogenesis in C57 BL/Ka mice: alterations to thymic microenvironment and lymphopoiesis. Leuk Res 10:783-789.
Defresne M.P., Humblet C., Rongy A.M., Greimers R., Boniver J. (1990) Effect of interferon-gamma and tumor necrosis factoralpha on lymphoepithelial interaction within thymic nurse cells. Eur J Immunol 20:429-432.
Freedman A.S., Munro J.M., Rice G.E., Bevilacqua M.P., Morimoto C., Mcintype B.W., Rhynhart K., Pober J.S., Nadler L.M. (1990) Adhesion of human B cell to germinal centers in vitro involves VLA-4 and INCAM-110. Science 249:1030-1033.
Fuse Y., Senoo A., Imazeki N. (1991) Ultrastructure of follicular dendritic cells. Dendritic cells in lymphoid tissues , Y., Imai, J.G., Tew, E.C.M., Hoefsmit, Excerpta Medica, Amsterdam New York Oxford; 99-110.
Hiai H., Nishi Y., Kaneshima H., Buma O.Y., Nishizuka Y. (1985) Thymic lymphoid-stromal cell complexes in mice; in vitro assay and mechanism of the complex formation. Exp Hematol 13:215-220.
Hiramine C., Hojo K., Koseto M., Nakagawa T., Mukasa A. (1990) Establishment of a murine thymic epithelial cell line capable of inducing both thymic nurse cell formation and thymocyte apoptosis. Lab Invest 62:41-54.
Humphrey J.H., Grennan D., Sundram V. (1984) The origine of follicular dendritic cells in the mouse and the mechanism of trapping of immune complexes on them. Eur J Immunol 14:859-863.
Itoh T., Doi H., Chin S., Nishimura T., Kasahara S. (1988) Establishment of mouse thymic nurse cell clones from a spontaneous BALB/c thymic tumor. Eur J Immunol 18:821-824.
Koopman G., Parmentier H.K., Schuurman H.J., Newman W., Meijer C.J.L., Pals S.T. (1991) Adhesion of human B-cells to follicular dendritic cells involves both the lymphocyte function associated antigen 1/intercellular adhesion molecule 1 and very late antigen 4/vascular cell adhesion molecule 1 pathways. J Exp Med 173:1297-1304.
Lilet-Leclercq C., Radoux D., Heinen E., Kinet-Denoël C., Defraigne J.O., Houben-Defresne M.P., Simar L.J. (1984) Isolation of follicular dendritic cells from human tonsils and adenoids. I. Procedure and morphological characterization. J Immunol Meth 66:235-244.
Liu Y.J., Joshua D.E., Willia G.T., Smith C.A., Gordon J., MacLennan I.C.M. (1989) Mechanism of antigen-driven selection in germinal centres. Nature 342:929-931.
.
Nishikawa S.I., Ogawa M., Nishikawa S., Kunisada T., Kodama H. (1988) B lymphopoiesis on stromal cell clone: stromal cell clones acting on different stage of B cell differentiation. Eur J Immunol 18:1767-1771.
Nishimura T., Takeuchi Y., Ichihisa I., Gao X., Akatsuka A., Tamaoki N., Yagita H., Okumura K., Habu S. (1990) Thymic stromal cell clone with nursing activity supports the growth and differentiation of murine CD4 + 8+ thymocytes in vitro. J Immunol 145:4012-4017.
Petrasch S., Kosco M., Perez-Alvarez C., Brittinger G. (1991) Follicular dendritic cell associated proliferation of human lymphocyte in vitro. Dendritic cells in lymphoid tissues , Y., Imai, J.G., Tew, E.C.M., Hoefsmit, Excerpta Medica, Amsterdam New York Oxford; 141-148.
Reichert R.A., Gallatin W.M., Weissman L.L., Butcher C. (1984) Germinal center B-cells lack homing receptors necessary for normal lymphocyte recirculation. J Exp Med 157:813-827.
Tsunoda R., Yaginuma Y., Kojima M. (1980) Immunocytological studies on the constituent cells of the secondary nodules in human tonsils. Acta Pathol Jpn 30:33-57.
Tsunoda R., Kojima M. (1987) A light microscopical study of isolated follicular dendritic cell-clusters in human tonsils. Acta Pathol Jpn 37:575-585.
Tsunoda R., Cormann N., Heinen E., Lesage F., Kinet-Denoël C., Simar L.J. (1988) Immunohistochemical study on cultured FDCcluster enriched lymphoid cell populations. Adv Exp Med Biol 237:177-180.
Tsunoda R., Nakayama M., Onozaki K., Heinen E., Cormann N., Kinet-Denoël C., Kojima M. (1990) Isolation and long-term cultivation of human tonsil follicular dendritic cells. Virchow Arch [B] 59:95-105.
Velardi A., Mingari M.C., Moretta L., Grossi C.E. (1986) Functional analysis of cloned germinal center CD4+ cells with natural killer cell-related features: Divergence from typical T helper cells. J Immunol 137:2808-2813.
Vollger L.W., Tuck D.T., Springer T.A., Haynes B.F., Singer K.H. (1987) Thymocyte binding to human thymic epithelial cells is inhibited by monoclonal antibodies to CD2 and LFA-3 antigens. J Immunol 138:358-363.
Wekerle H., Ketelsen U.P. (1980) Thymic nurse cells Ia-bearing epithelium involved in T-lymphocyte differentiation?. Nature 238:402-404.
Witte P.L., Robinson M., Henley A., Low M.G., Stiers D.L., Perkins S., Fleischman R.A., Kincade P.W. (1987) Relationships between B-lineage lymphocytes and stromal cells in long term cultures. Eur J Immunol 17:1473-1484.