Reference : Emperipolesis of lymphoid cells by human follicular dendritic cells in vitro.
Scientific journals : Article
Life sciences : Anatomy (cytology, histology, embryology...) & physiology
Emperipolesis of lymphoid cells by human follicular dendritic cells in vitro.
Tsunoda, R. [> > > >]
Nakayama, M. [> > > >]
Heinen, Ernst mailto [Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Histologie humaine >]
Miyake, K. [> > > >]
Suzuki, K. [> > > >]
Sugai, N. [> > > >]
Kojima, M. [> > > >]
Virchows Archiv. B: Cell Pathology
Springer Verlag
Yes (verified by ORBi)
[en] Antigens, Differentiation/metabolism ; Cell Adhesion/physiology ; Dendritic Cells/immunology/physiology/ultrastructure ; Humans ; Immunoenzyme Techniques ; Lymphocytes/physiology/ultrastructure ; Microscopy ; Microscopy, Phase-Contrast ; Palatine Tonsil/cytology
[en] Isolated follicular dendritic cells (FDCs) showed true and pseudoemperipolesis of fresh tonsillar lymphocytes, even after long-term (50-day) cultivation. Emperipolesis by FDCs was not restricted by allotype specificity, nor was it inhibited by the addition of antibodies against MHC-I & II antigens. Follicular dendritic cells predominantly engulfed B-cells; monocytes and macrophages were not found between FDC cytoplasmic extensions. When highly purified T-cell populations were added to FDC cultures emperipolesis of T-cells occurred, particularly those of the CD4-positive phenotype. Mitoses appeared within 6 h in the emperipolesed lymphocytes and, after an additional 18 h, some lymphocytes exhibited apoptosis.

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