[en] Mouse peritoneal macrophages were cultivated in vitro and treated with ethidium bromide (EB) or with cis-dichloro-diammine platinum (II) (cis-Pt). EB provokes strong cytological alterations and cell degeneration; cis-Pt was not toxic under our experimental contitions. EB-DNA complex penetrates into the macrophages, is liberated from DNA in vacuoles, then diffuses into the cell and is highly cytotoxic. Cis-Pt-DNA complex also penetrates into the cells, but cis-Pt cannot be released from DNA, cis-Pt-DNA complex accumulates inside cytoplasmic vacuoles but has no cytotoxic activity.
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Bibliography
Allison A.C., Young M.R. Vital staining and fluorescence microscopy of lysosomes. In: Lysosomes in Biology and Pathology , J.T., Dingle, H.B., Fell, North Holland Publishing Cy, Amsterdam; 1973, 600-628.
Altaner C., Matoska J. (1974) Avian sarcoma virus transformed hamster cells made resistant to ethidium bromide. J. Cell Sci. 16:603-621.
Axline S.G., Reaven E.P. (1974) Inhibition of phagocytosis and plasma membrane mobility of the cultivated macrophage by cytochalasine B. J. Cell Biol. 62:647-659.
Barka T., Anderson P.J. Histochemistry, theory, practice and bibliography, Harper and Row Publishers Inc., Hoeber. New York; 1963.
.
Chèvremont M., Chèvremont-Comhaire S. (1953) Recherches sur le trihydroxy-N-méthylindole et l’adrénochrome en culture de tissus. I. Action sur la croissance et la mitose. II. Action sur le chondriome. Arch. Biol. 64:399-437.
Desaive C., Keinen E., Bassleer R., Calberg-Bacq C.M. (1977) Comparaison des effets du bromure d’éthidium et du complexe bromure d’éthidium-acide désoxyribonucléique dans des cellules tumorales d’Ehrlich. C.R. Acad. Sci., Paris 284:1485-1488.
Geuskens M. (1971) A study of the effects of ethidium bromide on the ultrastructure of sea urchin embryos. J. exp. Zool. 178:247-255.
Gitler C., Rubalcava B., Caswell A. (1969) Fluorescence changes of ethidium bromide or binding to erythrocyte and mitochondrial membranes. Biochim. Biophys. Acta 193:470-471.
Heinen E. (1975) Etude des inclusions intramitochondriales provoquées par le bromure d’éthidium dans des cellules normales ou cancéreuses. J. Microsc. 22:21-28.
.
Heinen E., Bassleer R. (1976) Cytological and cytochemical analysis of the effects of cis-dichloro-diammino platinum (II) on chick fibroblasts cultivated in vitro. Chemotherapy 22:253-261.
Heinen E., Bassleer R. (1976) Mode of action of cis-dichloro-diammino platinum (II) on mouse Ehrlich ascites tumour cells. Biochem. Pharmacol. 25:1871-1875.
Heinen E., Bassleer R., Calberg-Bacq C.M., Desaive C., Lepoint A. (1974) Comparative study of the effects of ethidium bromide and DNA-ethidium bromide complex on normal and cancer cells. Biochem. Pharmacol. 23:1549-1551.
Heinen E., Desaive C., Houssier C., Gillet M.C. (1976) Effects du complexe cis-dichloro-diammine platine (II)-ADN sur des cellules normales ou cancéreuses. C.R. Soc. Biol. 170:919-921.
Heinen E., Lepoint A., Bassleer R., Goessens G. (1974) Effects of ethidium bromide on chick fibroblasts and mouse Ehrlich tumour cells cultivated in vitro. Cytological and cytochemical observations. Beitr. Path. 153:353-369.
Millard M.M., Macquet J.P., Theophanides T. (1975) X-ray photoelectron spectroscopy of DNA-Pt complexes. Evidence of O6(Gua)-N7(Gua) chelation of DNA with cis-dichloro-diammino platinum. Biochem. Biophys. Acta 402:166-170.
Rabinovitch M., Destefano J. (1974) Macrophage spreading in vitro. III. The effect of metabolic inhibitors, anesthetics and other drugs on spreading induced by subtilisin. Exp. Cell Res. 88:153-162.
Rosenberg B., Van Camp L., Grimley E.B., Thompson A.J. (1967) The inhibition of growth or cell division in Escherichia coli by different ionic species of platinum complexes. J. Biol. Chem. 242:1347-1365.
Simard R., Bernhard W. (1966) Le phénomène de la ségrégation nucléolaire: spécificité d’action de certains antimétabolites. Int. J. Cancer 1:463-479.
Trouet A., Deprez-De Campeneere D., De Duve C. (1972) Chemotherapy through lysosomes with a DNA-daunorubicin complex. Nature (New Biol.) 239:110-112.
Trouet A., Deprez-De Campeneere D., De Smedt-Malengreaux M., Atassi G. (1974) Experimental leukemia chemotherapy with a “lysosomotropic” adriamycin-DNA complex. Europ. J. Cancer 10:405-411.
Van Assel S., Steinen M. (1968) Inhibition sélective de la replication du DNA kinétoplastique des trypanosomides par le bromure d’éthidium. Arch. int. Physiol. Bioch. 76:388-389.
Waring M.J. (1965) Complex formation between ethidium bromide and nucleic acids. J. molec. Biol. 13:269-282.
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