Comparative ultrastructural study of the effects of serum-free medium and dibutyryl-cyclic AMP on newborn rat astroblasts.

Moonen, Gustave; Heinen, Ernst; Goessens, Guy

doi:10.1007/BF00224329

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Comparative ultrastructural study of the effects of serum-free medium and dibutyryl-cyclic AMP on newborn rat astroblasts.

Moonen, Gustave; Heinen, Ernst; Goessens, Guy

1976 • In Cell and Tissue Research, 167 (2), p. 221-7

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/23191

DOI
10.1007/BF00224329

PubMed
177214

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Keywords :

Animals; Animals, Newborn; Astrocytes/drug effects/ultrastructure; Blood; Bucladesine/pharmacology; Cell Adhesion/drug effects; Cell Differentiation/drug effects; Culture Media; Neuroglia/drug effects; Rats

Abstract :

[en] Modifications of cell shape induced in cultured newborn rat astroblasts by serum deprivation or dibutyryladenosine 3'-5' monophosphate (dBcAMP) are described. Serum suppression modifies the adhesitivity of the cells to the substrate, but this modification is not consistent with a true differentiation. The main ultrastructural feature of dBcAMP-treated astroblasts is the presence of an extensive system of 90 A microfilaments, while control cells are relatively devoid of these structures.

Disciplines :

Anatomy (cytology, histology, embryology...) & physiology

Author, co-author :

Moonen, Gustave ; Centre Hospitalier Universitaire de Liège - CHU > Neurologie Sart Tilman

Heinen, Ernst ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Histologie humaine

Goessens, Guy ; Université de Liège - ULiège > Services généraux (Faculté des sciences) > Relations académiques et scientifiques (Sciences)

Language :

English

Title :

Comparative ultrastructural study of the effects of serum-free medium and dibutyryl-cyclic AMP on newborn rat astroblasts.

Publication date :

1976

Journal title :

Cell and Tissue Research

ISSN :

0302-766X

eISSN :

1432-0878

Publisher :

Springer Science & Business Media B.V., New York, United States - New York

Volume :

167

Issue :

Pages :

221-7

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 22 September 2009

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Bibliography

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Grobstein C. (1958) Differentiation of vertebrate cells. The cell , J., Brachet, A., Mirsky, Academic Press, New York; 437-496.
Klier G., Schubert D., Heinemann S. (1975) Ultrastructural changes accompanying the induced differensstiation of clonal rat nerve and glia. Neurobiology 5:1-37.
Lim R., Mitsunobu K., Li W.K.P. (1973) Maturation-stimulating effect of brain extract and dibutyryl cyclic AMP on dissociated embryonic brain cells in culture. Exp. Cell Res. 79:243-246.
McIntyre E.H., Wintersgill Č.J., Perkins J.P., Vatter A.E. (1972) The responses in culture of human tumour astrocytes and neuroblasts to N⁶,O²-dibutyryl adenosine 3′,5′-monophosphoric acid. J. Cell Sci. 11:639-667.
Moonen G., Cam Y., Sensenbrenner M., Mandel P. (1975) Variability of the effects of serum-free medium, dibutyryl-cyclic AMP or theophylline on the morphology of cultured newborn rat astroblasts. Cell Tiss. Res. 163:365-372.
Schubert D. (1975) Induced differentiation of clonal rat nerve and glial cells. Neurobiology 4:376-387.
Shapiro D.L. (1973) Morphological and biochemical alterations in foetal rat brain cells cultured in the presence of monobutyryl cyclic AMP. Nature (Lond.) 241:203-204.