Reference : Thymus Gland, Neuroendocrinology
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Human health sciences : Endocrinology, metabolism & nutrition
Human health sciences : Immunology & infectious disease
Thymus Gland, Neuroendocrinology
Geenen, Vincent mailto [Université de Liège - ULiège > > Centre d'immunologie - Embryologie >]
Robert, Françoise [> >]
Ericsson, Anders [Karolinska Institutet > Laboratory of Molecular Biology > > >]
Persson, Hakan [Karolinska Institutet > Laboratory of Molecular Neurobiology > > >]
The Neuroscience Year, Supplement 2 to the Encyclopedia of Neuroscience
Smith, Barry
Adelman, George
Birkhäuser Verlag
[en] T-cell differentiation occurs primarily within the thymus and is regulated through intimate intercellular contacts, interactions between major histocompatibility proteins and the T-cell receptor complex, as well as exchanges of peptide signals between immature lymphocytes and thymic environmental cellular populations. There is now ample evidence that neuropeptide-lymphocyte interactions occur at multiple levels in the thymus, and that the sources of neuropeptides are encountered in different sites such as thymic innervating fibers, stromal cells, and developing thymocytes themselves. An important question to consider is the fact that neuropeptides are intrinsic components of the 'self' molecular structure, and therefore may contribuye to the induction of T-cell self tolerance. After immature thymocytes have escaped the deletion process of clones highly reactive for 'self' peptides, thymic neuropeptides could also represent accessory signals for activation (or inhibition) steps in the developmental programme of the T-cell system.
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS

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