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Poster (Scientific congresses and symposiums)
Combine pedigree and marker information into a single estimator for the calculation of relationships
Bömcke, Elisabeth; Gengler, Nicolas
2009ESF Conservation Genetics Conference – Integrating population genetics and conservation biology
 

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Abstract :
[en] Relationship coefficients are particularly useful to improve genetic management of endangered populations. Estimation of relationships was traditionally based on pedigree data but, today, numerous methods already exist to replace pedigrees by molecular data. However, genotyping a complete population for a sufficient number of markers can be impossible, e.g., in case of local and/or rare breeds. The idea was therefore to develop a new method to estimate relationship by combining molecular with pedigree data into a single estimator. Originally developed for the management of an endangered horse population, it will be useful for specific situations, where neither pedigree nor molecular data are complete. Two questions appeared: What and how to combine? Following the principle that things have to be similar to be combined, we compared two coefficients that have the advantage to be similarly defined: the additive relationship coefficient (axy) calculated from pedigrees and the total allelic relationship (taxy) obtained from markers. Wright relationship coefficient (rped,xy) were also compared to taxy, transformed into rmol,xy, to highlight the influence of inbreeding. The results showed the influence of inbreeding, of marker quality and the tendency of molecular coefficients to overestimate the relationship among individuals. The method to combine the selected coefficients was also determined. Various parameters were taken into account in the model: number of markers and quality (e.g. marker informativeness), mutation rate, pedigree quality (e.g. generation-equivalents), … The combined estimator has several advantages. Especially, negative relationship values obtained in literature with molecular-based estimators in case of small inbred populations can be avoided.
Disciplines :
Genetics & genetic processes
Animal production & animal husbandry
Author, co-author :
Bömcke, Elisabeth ;  Université de Liège - ULiège > Gembloux Agro-Bio Tech > Gembloux Agro-Bio Tech
Gengler, Nicolas  ;  Université de Liège - ULiège > Gembloux Agro-Bio Tech > Gembloux Agro-Bio Tech
Language :
English
Title :
Combine pedigree and marker information into a single estimator for the calculation of relationships
Publication date :
May 2009
Event name :
ESF Conservation Genetics Conference – Integrating population genetics and conservation biology
Event organizer :
European Science Foundation (ESF)
Event place :
Trondheim, Norway
Event date :
du 23 au 26 mai 2009
Audience :
International
Funders :
FRIA - Fonds pour la Formation à la Recherche dans l'Industrie et dans l'Agriculture [BE]
Available on ORBi :
since 17 September 2009

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