Reference : GBM cells from the tumour mass versus the subventricular zone: molecular and function...
Scientific congresses and symposiums : Poster
Human health sciences : Oncology
http://hdl.handle.net/2268/214296
GBM cells from the tumour mass versus the subventricular zone: molecular and functional characterisation
English
[fr] Caractérisation moléculaire et fonctionnelle des cellules de glioblastome issues de la masse tumorale ou de la zone sous-ventriculaire
Di Gregorio, Marina mailto [Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques >]
willems, Estelle mailto []
Dedobbeleer, Matthias mailto [Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, et biochimie humaine >]
Lumapat, Paul Noel mailto [Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, et biochimie humaine >]
Leprince, Pierre mailto [Université de Liège - ULiège > > GIGA - Neurosciences >]
ROGISTER, Bernard mailto [Centre Hospitalier Universitaire de Liège - CHU > > Service de neurologie >]
Scholtes, Félix mailto [Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Neuro-anatomie >]
May-2017
A0
No
International
Brain Tumor Meeting 2017, Berlin
18 et 19 Mai 2017
The Max Delbrück Center
Berlin
Allemagne
[en] Glioblastoma ; Relapse ; subventricular zone
[en] Life expectancy after diagnosis of glioblastoma (GBM) remains poor even with the best available treatment. This catastrophic survival is the direct consequence of systematic tumour recurrence.
It has previously been demonstrated that the subventricular zone (SVZ, a neurogenic niche of the adult central nervous system) attracts and harbours GBM cells, expressing stem cell biomarkers that act like glioblastoma-initiating cells. These cells hosted in the SVZ may be responsible for tumour recurrence. To better understand the difference between cells from the tumour mass (TM) and those migrating to the SVZ, this project will focus on two axes. First, a proteomic and transcriptomic approach will be used to identify one or more biomarkers that might help to establish if recurrences originate from the TM or the SVZ. The second aim of the project is to compare these two populations of cells from a functional point of view.
Some functional differences have already been observed: cells derived from SVZ form more spheroids than those derived from TM (1). U87MG cells from SVZ also form tumours more easily in mice compared to cells derived from the TM (2). However, preliminary results in chemo- and radioresistance assays on the cultured cells (U87MG) do not show significant differences between the two populations. Therefore, it might be the SVZ environment that plays a key role in therapeutic resistance, rather than intrinsic biological differences of cells from the TM versus the SVZ.
Laboratory of Nervous System Disorders and Therapy, GIGA-Neuroscience, University of Liège, Liège, Belgium
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS et télévie
GBM cells from the tumour mass versus the subventricular zone: molecular and functional characterisation
Researchers ; Professionals
http://hdl.handle.net/2268/214296

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