[en] Polymeric nanoparticles have been extensively investigated for their biomedical applications especially as drug carriers. There has been much research on multifunctional polymeric nanoparticles for the controlled release and targeted delivery of hydrophobic drugs. However, efficient encapsulation and delivery of hydrophilic therapeutics especially peptides/proteins still presents significant challenges.
This project aims to develop a novel one-pot strategy to obtain well-defined cross-linked nanoparticles able to carry peptides/proteins in their core, as along with targeting and/or imaging agents on their surface. In addition to this objective, the polymerisations will be carried out in supercritical carbon dioxide (scCO2), which confers environmentally benign features to the process.
Here, we investigate the feasibility of free radical dispersion polymerizations of 2-hydroxyethyl methacrylate (HEMA) in scCO2. In order to ensure the successful dispersion in scCO2 novel diblock CO2-philic surfactants are employed. These diblock surfactants are formed from two different segments, a CO2-phobic block which has an affinity to the growing particles and a second CO2-philic block that ensures surfactant solubility.
Research Center/Unit :
Center for Education and Research on Macromolecules (CERM) CESAM - Complex and Entangled Systems from Atoms to Materials - ULiège
Disciplines :
Materials science & engineering Chemistry
Author, co-author :
Parilti, Rahmet ; University of Liège - ULiège > Complex and Entangled Systems from Atoms to Materials (CESAM), Center for Education and Research on Macromolecules (CERM)
Jérôme, Christine ; University of Liège - ULiège > Complex and Entangled Systems from Atoms to Materials (CESAM), Center for Education and Research on Macromolecules (CERM)
Howdle, Steven M.; University of Nottingham, School of Chemistry, UK
Language :
English
Title :
Synthesis of cross-linked nanoparticles in supercritical carbon dioxide for protein delivery
