[en] This project aims to develop a novel one-pot strategy to obtain well-defined cross-linked particles able to carry peptides/proteins in their core, as along with targeting and/or imaging agents on their surface. In addition to this objective, polymerisations will be carried out in supercritical carbon dioxide (scCO2), which confers environmentally benign features to the process.
Here, we investigate the feasibility of free radical dispersion polymerizations of 2-hydroxyethyl methacrylate (HEMA) in scCO2. In order to ensure the successful dispersion in scCO2 novel diblock CO2-philic surfactants are employed. These diblock surfactants are formed from two different segments, a CO2-phobic block which has an affinity to the growing particles and a second CO2-philic block that ensures surfactant solubility.
Research Center/Unit :
Center for Education and Research on Macromolecules (CERM) CESAM - Complex and Entangled Systems from Atoms to Materials - ULiège
Disciplines :
Materials science & engineering Chemistry
Author, co-author :
Parilti, Rahmet ; University of Liège - ULiège > Complex and Entangled Systems from Atoms to Materials (CESAM), Center for Education and Research on Macromolecules (CERM)
Howdle, Steven M.; University of Nottingham, School of Chemistry, United Kingdom
Jérôme, Christine ; University of Liège - ULiège > Complex and Entangled Systems from Atoms to Materials (CESAM), Center for Education and Research on Macromolecules (CERM)
Language :
English
Title :
Synthesis of cross-linked P(HEMA) particles in supercritical carbon dioxide for protein delivery
Publication date :
22 May 2017
Event name :
Advanced Polymers via Macromolecular Engineering (APME)
Event place :
Ghent, Belgium
Event date :
21/05/2017 - 25/05/2017
Audience :
International
Funders :
BELSPO - SPP Politique scientifique - Service Public Fédéral de Programmation Politique scientifique The International Doctoral School Nanofar
