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Polyvinylamine based copolymers for gene delivery
Dréan, Mathilde; Debuigne, Antoine; Guégan, Philippe et al.
2016International Doctoral School in Functional Materials (IDS-FunMat)
 

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Keywords :
biomaterial; nanomedicine; gene therapy
Abstract :
[en] Gene delivery consists in the insertion of functional genes in the cells of a patient in order to correct a specific genetic defect responsible for diseases. The synthetic vehicles attract more and more attention today due to their lower immunogenicity, ability to carry larger DNA loads and their possible large scale production. The use of nano-complexes between polycations and the negatively charged DNA molecules is the most widespread polymer-based transfection mode. Polyethyleneimine (PEI) is the most common and efficient non-viral gene transfer agent but some alternatives which can improve transfection efficacy and low toxicities are under researches. The polyvinylamine (PVAm), another polycation with a high charge density, has been investigated but these studies are limited to unmodified PVAm chains. In this project, we exploit the latest progress in the field of controlled radical polymerization (CRP) for designing well-defined and advanced functional PVAm derivatives devoted to gene therapy application and establish a structure-gene transfer activity relationship. Incorporation of appropriate pH-responsive moieties, like the vinylimidazole, able to play the role of “protons pumps” as well as introduction of biocompatible segments in the PVAm will be considered in order to facilitate the release of nucleic acids chains in the cytoplasm and improve the biocompatibility of the carrier, respectively.
Research center :
Center for Education and Research on Macromolecules (CERM)
Disciplines :
Chemistry
Materials science & engineering
Author, co-author :
Dréan, Mathilde;  University of Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Debuigne, Antoine  ;  University of Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Guégan, Philippe;  University Pierre et Marie Curie, Institut Parisien de Chimie Moléculaire, Team "Chimie des Polymères" (LCP) Paris, France
Rieger, Jutta ;  University Pierre et Marie Curie, Institut Parisien de Chimie Moléculaire, Team "Chimie des Polymères" (LCP) Paris, France
Language :
English
Title :
Polyvinylamine based copolymers for gene delivery
Publication date :
16 March 2016
Event name :
International Doctoral School in Functional Materials (IDS-FunMat)
Event place :
Bordeaux, France
Event date :
13/03/2016 - 18/03/2016
Funders :
The International Doctoral School IDS-Funmat
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
Commentary :
This oral communication was presented by Mathilde Dréan
Available on ORBi :
since 24 May 2017

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