Reference : Polyvinylamine based copolymers for gene delivery
Scientific congresses and symposiums : Unpublished conference/Abstract
Physical, chemical, mathematical & earth Sciences : Chemistry
Engineering, computing & technology : Materials science & engineering
http://hdl.handle.net/2268/211077
Polyvinylamine based copolymers for gene delivery
English
Dréan, Mathilde [University of Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)]
Debuigne, Antoine mailto [University of Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)]
Guégan, Philippe [University Pierre et Marie Curie, Institut Parisien de Chimie Moléculaire, Team "Chimie des Polymères" (LCP) Paris, France > > > >]
Rieger, Jutta [University Pierre et Marie Curie, Institut Parisien de Chimie Moléculaire, Team "Chimie des Polymères" (LCP) Paris, France > > > >]
16-Mar-2016
No
No
National
International Doctoral School in Functional Materials (IDS-FunMat)
13/03/2016 - 18/03/2016
Bordeaux
France
[en] biomaterial ; nanomedicine ; gene therapy
[en] Gene delivery consists in the insertion of functional genes in the cells of a patient in order to correct a specific genetic defect responsible for diseases. The synthetic vehicles attract more and more attention today due to their lower immunogenicity, ability to carry larger DNA loads and their possible large scale production. The use of nano-complexes between polycations and the negatively charged DNA molecules is the most widespread polymer-based transfection mode. Polyethyleneimine (PEI) is the most common and efficient non-viral gene transfer agent but some alternatives which can improve transfection efficacy and low toxicities are under researches. The polyvinylamine (PVAm), another polycation with a high charge density, has been investigated but these studies are limited to unmodified PVAm chains.
In this project, we exploit the latest progress in the field of controlled radical polymerization (CRP) for designing well-defined and advanced functional PVAm derivatives devoted to gene therapy application and establish a structure-gene transfer activity relationship. Incorporation of appropriate pH-responsive moieties, like the vinylimidazole, able to play the role of “protons pumps” as well as introduction of biocompatible segments in the PVAm will be considered in order to facilitate the release of nucleic acids chains in the cytoplasm and improve the biocompatibility of the carrier, respectively.
Center for Education and Research on Macromolecules (CERM)
The International Doctoral School IDS-Funmat ; Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS
Researchers
http://hdl.handle.net/2268/211077
This oral communication was presented by Mathilde Dréan

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