Reference : Design of polyphosphoester coplymers as scaffolds for tissue engineering applications
Scientific congresses and symposiums : Poster
Physical, chemical, mathematical & earth Sciences : Chemistry
Engineering, computing & technology : Materials science & engineering
http://hdl.handle.net/2268/210978
Design of polyphosphoester coplymers as scaffolds for tissue engineering applications
English
Shah, Urmil [University of Liège - ULiège > Complex and Entangled Systems from Atoms to Materials (CESAM), Center for Education and Research on Macromolecules (CERM)]
Ergül, Zeynep [University of Liège - ULiège > Complex and Entangled Systems from Atoms to Materials (CESAM), Center for Education and Research on Macromolecules (CERM)]
Jérôme, Christine mailto [University of Liège - ULiège > Complex and Entangled Systems from Atoms to Materials (CESAM), Center for Education and Research on Macromolecules (CERM)]
4-May-2017
No
No
National
Belgian Polymer Group (BPG) Annual Meeting
04/05/2017 - 05/05/2017
Houffalize
Belgium
[en] ring-opening polymerization (ROP) ; polyphosphate
[en] Polymers with repeating phosphoester linkages in the backbone are biodegradable and emerged as a promising class of novel biomaterials. In contrast to polyesters, the pentavalency of the phosphorus atom offers a large diversity of structures and as a consequence a wide range of properties for these materials. This study aims at taking profit of this easy functionalization to synthesize a series of degradable polymers of precisely tailored properties especially elasticity, hydrophilicity and functionality. We aim at developing a set of degradable materials in which only elasticity is varied keeping unchanged other parameters such as hydrophilicity, which remains quite a challenge.
For that purpose, we have synthesized by organocatalyzed ring-opening polymerization,random di- and terpolymers between various cyclic phosphoesters bearing a short side-chain (hydrophilic), a longer side-chain (hydrophobic) and an unsaturated side-chain (butenyl)able to cross-link under UV irradiation. Playing on the composition of these copolymers, the cross-linking density and the hydrophilicity can be tuned quite independently. In the future, these materials will be used as model scaffolds to study the growth and differentiation of stem cells.
Center for Education and Research on Macromolecules (CERM) ; CESAM Complex and Entangled Systems from Atoms to Materials (CESAM)
Researchers
http://hdl.handle.net/2268/210978
This poster was presented by Urmil Shah

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