[en] Genotoxic stress is a well-known inducer of pre-mRNa alternative splicing . In this work, we aim at identifying keys componants of the signaling cascade linking the DNA lesion to the splcing machiney.and thus gain better knowledge od the molecular mechanism controling large scale splcing decision in stress situation. Nous avons établi que C-Jun est important pour l'épissage alternatif de nombreux ARN pré-messagers.
Research Center/Unit :
Giga-Signal Transduction - ULiège
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Deward, Adeline
Gabriel, Maude
Klinck, Roscoe
Chabot, Benoit
Figueroa, Maximiliano
Piette, Jacques ; Université de Liège > Département des sciences de la vie > GIGA-R : Virologie et immunologie