Reference : Polyphosphoester containing amphiphilic block copolymers as drug nanocarriers
Scientific congresses and symposiums : Poster
Engineering, computing & technology : Materials science & engineering
Physical, chemical, mathematical & earth Sciences : Chemistry
http://hdl.handle.net/2268/201764
Polyphosphoester containing amphiphilic block copolymers as drug nanocarriers
English
Ergül, Zeynep [University of Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)]
Vanslambrouck, Stéphanie [University of Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)]
Thiry, Justine [University of Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)]
Debuigne, Antoine mailto [University of Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)]
Lecomte, Philippe mailto [University of Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)]
Jérôme, Christine mailto [University of Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)]
Riva, Raphaël [University of Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)]
12-Sep-2016
No
No
National
PAI Annual Meeting
12/09/2016
Liège
Belgium
[en] nanomedicine
[en] The design of drug delivery systems often requires biodegradable and biocompatible materials that allow safe retention and controlled release of the drug. In this respect, supramolecularly self-assembled amphiphilic block copolymers into spherical micelles are appropriate carriers for poorly soluble drugs. In that framework, we have designed novel functional poly(ethylene oxide)-b-polyphosphoester amphiphilic block copolymers able to cross-linked under UV and degrade in response to a reduction of the pH from neutral conditions. Therefore, an unsaturated alkene side-chain was introduced on the cyclic phosphate monomer according to a one-step reaction followed by its organocatalyzed polymerization initiated by a poly(ethylene oxide) macroinitiator. After self-assembly into water, the micelles were cross-linked by UV irradiation. Then, these cross-linked micelles have been loaded by doxorubicin, i.e. a drug used in cancer therapy. We observed that the doxorubicin loading increased with the number of double bonds on the polyphosphate block of non-cross-linked micelles. This diblock amphiphilic copolymer bearing pendant unsaturations appears thus particularly promising candidate to build micellar drug delivery systems for intravenous injection.
Center for Education and Research on Macromolecules (CERM)
The International Doctoral School Nanofar ; Politique Scientifique Fédérale (Belgique) = Belgian Federal Science Policy
Researchers
http://hdl.handle.net/2268/201764
This poster was presented by Zeynep Ergul Yilmaz

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