[en] This very short review aims at analyzing the current biochemical view of the molecular steps involved in the peptide hormone synthesis, going from the gene to the final active peptide.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Martial, Joseph ; Université de Liège - ULiège > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire
Language :
English
Title :
Peptide hormones: from the transcription of the gene to the final product--a biochemical view
Chretien, M.; Seidah, N.G.: Precursor polyprotein in endocrine and neuroendocrine systems. Int. J. Pept. Protein Res. 23: 335-341 (1984).
Miller, W.L.; Eberhardt, N.L.: Structure and evolution of the growth hormone gene family. Endocr. Rev. 4: 97-130 (1983).
Truong, A.T.; Duez, C.; Belayew, A.; Renard, A.; Pictet, R.; Bell, G.I.; Martial, J.A.: Isolation and characterization of the human prolactine gene. EMBO J. 3; 429-437 (1984).
Whitfeld, P.L.; Seeburg, P.H.; Shine, J.: The human proopiomelanocortin gene: organization, sequence, and interspersion with repetitive DNA. DNA 1: 133-143 (1982).
Comb, M.; Rosen, H.; Seeburg, P.; Adelman, J.; Herbert, E.: Primary structure of the human proenkephalin gene. DNA 2: 213-229 (1983).
Suda, M.; Nakao, K.; Yoshimasa, T.; Ikeda, Y.; Sakamoto, M.; Yanaihara, N.; Numa, S.; lmura, H.: A novel opioid peptide, leumorphin, acts as an agonist at the kappa opiate receptor. Life Sci. 32: 2769-2775 (1983).
Evans, R.M.; Amara, S.G.; Rosenfeld, M.G.: RNA processing regulation of neuroendocrine gene expression. DNA 1: 323-328 (1982).
Lundblad, J.R.; Roberts, J.L.: Regulation of proopiomelanocortin gene expression in pituitary. Endocr. Rev. 9: 135-158 (1988).
Lecomte, C.; Renard, A.; Martial, J.A.: A new natural hGH variant - 17.5 kd - produced by alternative splicing. An additional consensus sequence which may play a role in branchpoint selection. Nucleic Acids Res. 15: 6331-6348 (1987).
Lingappa, V.R.; Blobel, G.: Early events in the biosynthesis of secretory and membrane proteins: the signal hypothesis. Recent Prog. Horm. Res. 36: 451-475 (1980).
Loh, Y.P.; Brownstein, M.J.; Gainer, H.: Proteolysis in neuropeptide processing and other neural functions. Annu. Rev. Neurosci. 7; 189-222 (1984).
Eipper, B.A.; Glembotski, C.C.; Mains, R.E.; Selective loss of alpha-melanotropin-amidating activity in primary cultures of rat intermediate pituitary cells. J. Biol. Chem. 258: 7292-7298 (1983).
Weber, E.; Esch, F.S.; Böhlen, P.; Paterson, S.; Corbett, A.D.; McKnight, A.T.; Kosterlitz, H.W.; Barchas, J.O.; Evans, C.J.; Metorphamide: isolation, structure and biologic activity of an amidated opioid octapeptide from bovine brain. Proc. Natl. Acad. Sci. USA 80: 7362-7366 (1983).
Mutt, V.; Jorpes, E.: Hormonal polypeptides of the upper intestine. Biochem. J. 125: 57P-68P (1971).
Hubbard, S.C.; Ivatt, R.J.P.: Synthesis and processing of aspargine-linked oligosaccharides. Annu. Rev. Biochem. 50: 555-584 (1981).
