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Article (Scientific journals)
The evolutionarily conserved Kruppel-associated box domain defines a subfamily of eukaryotic multifingered proteins
Bellefroid, Eric J.; Poncelet, Dominique A; Lecocq, Pierre J et al.
1991In Proceedings of the National Academy of Sciences of the United States of America, 88 (9), p. 3608-12
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Keywords :
Amino Acid Sequence; Cloning, Molecular; DNA/genetics; DNA-Binding Proteins/*chemistry/genetics; Gene Library; Humans; Juvenile Hormones/*chemistry/genetics; Kruppel-Like Transcription Factors; Molecular Sequence Data; *Repressor Proteins; *Transcription Factors; Tumor Cells, Cultured; *Zinc Fingers
Abstract :
[en] We have previously shown that the human genome includes hundreds of genes coding for putative factors related to the Kruppel zinc-finger protein, which regulates Drosophila segmentation. We report herein that about one-third of these genes code for proteins that share a very conserved region of about 75 amino acids in their N-terminal nonfinger portion. Homologous regions are found in a number of previously described finger proteins, including mouse Zfp-1 and Xenopus Xfin. We named this region the Kruppel-associated box (KRAB). This domain has the potential to form two amphipathic alpha-helices. Southern blot analysis of "zoo" blots suggests that the Kruppel-associated box is highly conserved during evolution. Northern blot analysis shows that these genes are expressed in most adult tissues and are down-regulated during in vitro terminal differentiation of human myeloid cells.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Bellefroid, Eric J.;  Université de Liège - ULiège
Poncelet, Dominique A;  Université de Liège - ULiège
Lecocq, Pierre J;  Université de Liège - ULiège
Revelant, Olivier;  Université de Liège - ULiège
Martial, Joseph ;  Université de Liège - ULiège > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire
Language :
English
Title :
The evolutionarily conserved Kruppel-associated box domain defines a subfamily of eukaryotic multifingered proteins
Publication date :
1991
Journal title :
Proceedings of the National Academy of Sciences of the United States of America
ISSN :
0027-8424
eISSN :
1091-6490
Publisher :
National Academy of Sciences, Washington, United States - District of Columbia
Volume :
88
Issue :
9
Pages :
3608-12
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 27 August 2009

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