No full text
Article (Scientific journals)
Jean Marquet Award. Regeneration of the neurosensory structures in the mammalian inner ear.
Lefèbvre, Philippe; Malgrange, Brigitte; Van de Water, T. et al.
1997In Acta Oto-Rhino-Laryngologica Belgica, 51 (1), p. 1-10
Peer reviewed
 

Files


Full Text
No document available.

Send to



Details



Keywords :
Animals; Awards and Prizes; Belgium; Cells, Cultured; Ear, Middle/innervation; Growth Substances/pharmacology; Hair Cells, Vestibular/physiology; Mice; Nerve Regeneration/drug effects; Organ of Corti/physiology; Otolaryngology; Rats; Transforming Growth Factor alpha/pharmacology; Tretinoin/pharmacology; Vestibulocochlear Nerve/physiology
Abstract :
[en] Regeneration of the neurosensory structures in the mammalian inner ear. Motivated by the absence of treatment of neurosensory deafness apt to restore auditory function or alter the course of progressive hearing loss, we developed two different experimental strategies to approach these diseases: one is otoprotection, designed to prevent further degradation of auditory function; the other is regeneration which is defined as the replacement of hair cells in the deaf ear and their reconnection to the central nervous system through primary auditory neurons. In this paper, we summarize our data on the regeneration of auditory neurons and hair cells. Neuronal maintenance and regeneration was studied through an initial investigation of growth factors during inner development. Once the effect of various neurotrophic molecules was determined, the factors were tested on mature auditory neurons in vitro and in vivo. The hair cell regeneration was investigated on the basis of a concept derived from comparative physiology and from the study of the development of the inner ear. We showed that in young rats it is possible to induce the regeneration/repair of hair cells in the organ of Corti in cultures using retinoic acid and transforming growth factor alpha. The clinical prospects of these findings of inner ear regeneration are discussed.
Disciplines :
Otolaryngology
Author, co-author :
Lefèbvre, Philippe ;  Université de Liège > Département des sciences cliniques > Oto-rhino-laryngologie et audiophonologie
Malgrange, Brigitte  ;  Université de Liège > GIGA - Neurosciences
Van de Water, T.
Moonen, Gustave  ;  Université de Liège > Département des sciences cliniques > Département des sciences cliniques
Language :
English
Title :
Jean Marquet Award. Regeneration of the neurosensory structures in the mammalian inner ear.
Publication date :
1997
Journal title :
Acta Oto-Rhino-Laryngologica Belgica
ISSN :
0001-6497
Publisher :
Acta Medica Belgica, Belgium
Volume :
51
Issue :
1
Pages :
1-10
Peer reviewed :
Peer reviewed
Available on ORBi :
since 01 August 2016

Statistics


Number of views
134 (1 by ULiège)
Number of downloads
0 (0 by ULiège)

Scopus citations®
 
3
Scopus citations®
without self-citations
3

Bibliography


Similar publications



Contact ORBi