NT-3 combined with CNTF promotes survival of neurons in modiolus-spiral ganglion explants.

Staecker, H.; Liu, W.; Hartnick, C.; Lefèbvre, Philippe; Malgrange, Brigitte; Moonen, Gustave; Van de Water, T. R.

doi:10.1097/00001756-199507310-00017

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NT-3 combined with CNTF promotes survival of neurons in modiolus-spiral ganglion explants.

Staecker, H.; Liu, W.; Hartnick, C. et al.

1995 • In Neuroreport, 6 (11), p. 1533-7

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/200728

DOI
10.1097/00001756-199507310-00017

PubMed
7579142

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Keywords :

Animals; Brain-Derived Neurotrophic Factor; Cell Survival/drug effects; Ciliary Neurotrophic Factor; Cochlear Nucleus/cytology/drug effects; Hair Cells, Auditory/metabolism; Nerve Growth Factors/biosynthesis/pharmacology; Nerve Tissue Proteins/pharmacology; Neurons/drug effects; Neurotrophin 3; Rats; Rats, Wistar; Spiral Ganglion/cytology/drug effects

Abstract :

[en] Auditory neurons depend upon the integrity of both their peripheral (auditory hair cells) and central (cochlear nucleus) targets for survival. One proposed trophic mechanism is the production of neurotrophin-3 (NT-3) by auditory hair cells. Modiolus-spiral ganglion explants from adult rats that closely mirror cell-cell interactions and in vivo tissue relationships within this ganglion provide a model for testing trophic factors. Brain derived neurotrophic factor (BDNF), NT-3 and ciliary neurotrophic factor (CNTF) were tested for their ability, both individually and in combination, to support neuronal survival. NT-3 was the strongest individual promoter of survival, while CNTF (a cytokine) with NT-3 (a neurotrophin) was the most effective combination for promoting the survival of auditory neurons.

Disciplines :

Otolaryngology

Author, co-author :

Staecker, H.

Liu, W.

Hartnick, C.

Lefèbvre, Philippe ; Université de Liège > Département des sciences cliniques > Oto-rhino-laryngologie et audiophonologie

Malgrange, Brigitte ; Université de Liège > GIGA - Neurosciences

Moonen, Gustave ; Université de Liège > Département des sciences cliniques > Département des sciences cliniques

Van de Water, T. R.

Language :

English

Title :

NT-3 combined with CNTF promotes survival of neurons in modiolus-spiral ganglion explants.

Publication date :

1995

Journal title :

Neuroreport

ISSN :

0959-4965

eISSN :

1473-558X

Publisher :

Lippincott Williams & Wilkins, United States

Volume :

Issue :

Pages :

1533-7

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 01 August 2016

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Bibliography

Ard M, Morest D and Haugher S. Neurosciences 16, 151-170 (1985).
Lefebvre PP, Leprince P, Weber T et al. Brain Res 507, 254-260 (1990).
Zhou Y and Van De Water TR. Acta Otolaryngol (Stockh) 104, 90-98 (1987).
Lefebvre PP, Weber T, Rigo JM et al. Hearing Res 58, 185-192 (1992).
Spoendlin H. Biology of the cochleo-vestibular nerve. In: Alberti PW and Ruben RJ, eds. Otologic medicine and surgery, Vol. 1. New York: Churchill Livingstone, 1988: 117-150.
Ylikoski J, Pirvola U, Moshynakov M et al. Hearing Res 56, 69-78 (1993).
Farinas I, Jones K, Backus C et al. Nature 369, 658-661 (1994).
Bianchi L and Cohan C. Dev Biol 152, 353-365 (1993).
Staecker H, Liu W, Hartnick C et al. Abstracts of the Association for Research in Otolaryngology, XVIIth Midwinter Research Meeting Abst#549 (1994).
Avila M, Varela-Nieto I, Romero G et al. Dev Biol 159, 266-275 (1993).
Vasquez E, Van De Water TR, Del Valle M et al. Anat Embryol 189, 157-167 (1994).
Lefebvre P, Malgrange B, Staecker H et al. NeuroReport 5, 865-868 (1994).
Arakawa Y, Sendtner M and Thoenen H. J Neurosci 10, 3507-3515 (1990).
Sendtner M, Kreutzberg G and Thoenen H. Nature 345, 440-441 (1990).
Wong V, Arriaga R, Ip NY et al. Eur J Neurosci 5, 466-474 (1993).
Mitsumoto H, Ikeda K, Klinkosz B et al. Science 265, 1107-1110 (1994).
Lo DC. Proc Natl Acad Sci USA 90, 2557-2558 (1993).
Lefebvre PP, Van De Water TR, Weber T et al. Brain Res 567, 306-312 (1991).