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Sox9: a new player in hair cell differentiation
Delacroix, Laurence
2015The Belgian Society for Cell and developmental Biology Autumn meeting
 

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Keywords :
hearing; development; inner ear
Abstract :
[en] It is widely accepted that cell fate determination in the cochlea is tightly controlled by different factors that remain to be fully defined. Here, we show that Sox9, initially expressed in the entire sensory epithelium of the cochlea, progressively disappears from differentiating hair cells (HCs) and is finally restricted to supporting cells (SCs). The absence of Sox9 leads to supernumerary HCs production, and its overexpression blocks HCs differentiation even if co-expressed with Atoh1, a transcription factor necessary and sufficient to induce HCs. Sox9 reduces Atoh1 transcriptional activity by upregulating Hey1 and HeyL factors and genetic ablation of these genes induce extra HCs along the cochlea. Furthermore, we show that Sox9 is required for Notch-dependent inhibition of HC fate. Taken together, these data show that Sox9 contributes to Notch-dependent cochlear cell patterning by upregulating Hey1 and HeyL proteins in future SCs, thereby preventing Atoh1 from driving HC differentiation.
Disciplines :
Anatomy (cytology, histology, embryology...) & physiology
Author, co-author :
Delacroix, Laurence ;  Université de Liège > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques
Language :
English
Title :
Sox9: a new player in hair cell differentiation
Publication date :
November 2015
Event name :
The Belgian Society for Cell and developmental Biology Autumn meeting
Event place :
Leuven, Belgium
Event date :
November 23-24
Audience :
International
Available on ORBi :
since 05 July 2016

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