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Article (Scientific journals)
Structure of the tilapia (Oreochromis mossambicus) prolactin I gene
Swennen, D.; Poncelet, A. C.; Sekkali, B. et al.
1992In DNA and Cell Biology, 11 (9), p. 673-84
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Keywords :
Amino Acid Sequence; Animals; Base Sequence; Blotting, Southern; Cloning, Molecular; Dna; Humans; Molecular Sequence Data; Prolactin/*genetics; Restriction Mapping; Sequence Homology, Amino Acid; Tilapia; Transcription, Genetic
Abstract :
[en] The tilapia (Oreochromis mossambicus) prolactin-I (PRL-I) gene has been cloned and sequenced. Its transcript (3,677 bases long) begins with a guanine and is organized in five exons and four introns like the other known prolactin genes. Analysis of the 1,555-bp 5'-flanking region suggests that pituitary-specific expression of the gene could be regulated through a trans-factor related to the mammalian pituitary-specific factor Pit-1. Two potential binding sites for such a factor were found in the first intron, suggesting a possible regulatory role for this region. Moreover, two potential Z-DNA regions are located at positions -837 to -812 and -246 to -179 from the transcription start site. These two regions could play an important role in the regulation of PRL gene expression.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Swennen, D.
Poncelet, A. C.
Sekkali, B.
Rentier-Delrue, Françoise ;  Université de Liège - ULiège > Département des sciences de la vie > Biologie et génétique moléculaire - GIGA-R : Coordination scientifique
Martial, Joseph ;  Université de Liège - ULiège > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire
Belayew, A.
Language :
English
Title :
Structure of the tilapia (Oreochromis mossambicus) prolactin I gene
Publication date :
1992
Journal title :
DNA and Cell Biology
ISSN :
1044-5498
eISSN :
1557-7430
Publisher :
Mary Ann Liebert, Inc., Larchmont, United States - New York
Volume :
11
Issue :
9
Pages :
673-84
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 26 August 2009

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