The role of integrins in human embryo implantation

Merviel, P.; Challier, J. C.; Carbillon, L.; Foidart, Jean-Michel; Uzan, S.

doi:10.1159/000053942

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The role of integrins in human embryo implantation

Merviel, P.; Challier, J. C.; Carbillon, L. et al.

2001 • In Fetal Diagnosis and Therapy, 16 (6), p. 364-371

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https://hdl.handle.net/2268/19539

DOI
10.1159/000053942

PubMed
11694740

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Keywords :

Endometrium; Implantation window; Implantation; Integrins; Trophoblast

Abstract :

[en] Integrins are adhesion molecules present in endometrial, decidual, and extravillous cytotrophoblast (EVCT) cells. They participate in cell-cell adhesion as well as in adhesion between cells and components of the extracellular matrix, and they play an important role in the endometrial phenotype change that occurs during the secretory phase, the first stage of implantation. At the beginning of pregnancy, the change in integrin expression is synchronized with the trophoblast attachment (embryo-endometrium interactions with integrins v3, 41, 61, and 71) and the embryo's invasion of the decidua (integrins 64511141 switch from proliferative to endovascular EVCT). Several diseases, including preeclampsia, intrauterine growth retardation caused by vascular problems and defective luteal phases, may be explained by anomalies in integrin patterns.

Disciplines :

Reproductive medicine (gynecology, andrology, obstetrics)

Author, co-author :

Merviel, P.

Challier, J. C.

Carbillon, L.

Foidart, Jean-Michel ; Université de Liège - ULiège > Département des sciences cliniques > Gynécologie - Obstétrique - Labo de biologie des tumeurs et du développement

Uzan, S.

Language :

English

Title :

The role of integrins in human embryo implantation

Publication date :

2001

Journal title :

Fetal Diagnosis and Therapy

ISSN :

1015-3837

eISSN :

1421-9964

Publisher :

S. Karger

Volume :

Issue :

Pages :

364-371

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 21 August 2009

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