No full text
Article (Scientific journals)
Correlation between P450 CYP1A1 Indelibility, MsPI Genotype and Lung Cancer Incidence
Jacquet, Michèle; LAMBERT, Vincent; BAUDOUX, Etienne et al.
1996In European Journal of Cancer, 32A (10), p. 1701-1706
Peer Reviewed verified by ORBi
 

Files


Full Text
No document available.

Send to



Details



Abstract :
[en] The aim of this study was to verify a possible correlation between CYPlAl induction, MspI genotype and lung cancer incidence. A case-control study was performed on 48 lung cancer patients and 81 healthy subjects to test the existence of a correlation, within a European population. The hyperinducible group exhibited a significantly higher risk of lung cancer (odds ratio = 3.41; P = 0.036), especially for adenocarcinoma (odds ratio = 5.29; P = 0.033). In contrast with the situation observed in Asian populations, the tiequency of the M2 allele did not differ significantly in the total lung cancer population (7.82%) and the group of healthy subjects (10.71%). The median inducibility value was slightly higher among cancer patients with one or two M2 alleles than among patients homozygous for the wild-type allele (P = 0.09). However, the percentage of individuals possessing at least one mutated allele was not significantly higher among hyperinducible patients (37.5%) than among non-hyperinducible patients (16.0%). No significant correlation could be found between M2 allele and lung cancer or between M2 allele and CYplAZ inducibility; the only positive correlation found was between CYPlAZ hyperinduc- ibility and lung cancer incidence. Our observations do not support the view that the presence of the M2 allele at the MspI site of the CYPZAZ gene constitutes a significant lung cancer risk in Caucasians.
Disciplines :
General & internal medicine
Author, co-author :
Jacquet, Michèle;  Centre Hospitalier Universitaire de Liège - CHU > Service de Chimie Médicale
LAMBERT, Vincent  ;  Centre Hospitalier Universitaire de Liège - CHU > Ophtalmologie
BAUDOUX, Etienne  ;  Centre Hospitalier Universitaire de Liège - CHU > Thérapie cellulaire
Muller, M;  Institut Malvoz > Physiologie du Travail
Kremers, Pierre;  Centre Hospitalier Universitaire de Liège - CHU > Service de chimie médicale
Gielen, Jacques;  Centre Hospitalier Universitaire de Liège - CHU > Service de chimie Médicale
Language :
English
Title :
Correlation between P450 CYP1A1 Indelibility, MsPI Genotype and Lung Cancer Incidence
Publication date :
April 1996
Journal title :
European Journal of Cancer
ISSN :
0959-8049
eISSN :
1879-0852
Publisher :
Elsevier Science, Oxford, United Kingdom
Volume :
32A
Issue :
10
Pages :
1701-1706
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 08 October 2015

Statistics


Number of views
37 (3 by ULiège)
Number of downloads
0 (0 by ULiège)

Bibliography


Similar publications



Contact ORBi