Correlation between P450 CYP1A1 Indelibility, MsPI Genotype and Lung Cancer Incidence

The aim of this study was to verify a possible correlation between CYPlAl induction, MspI genotype and lung cancer incidence. A case-control study was performed on 48 lung cancer patients and 81 healthy subjects to test the existence of a correlation, within a European population. The hyperinducible group exhibited a significantly higher risk of lung cancer (odds ratio = 3.41; P = 0.036), especially for adenocarcinoma (odds ratio = 5.29; P = 0.033). In contrast with the situation observed in Asian populations, the tiequency of the M2 allele did not differ significantly in the total lung cancer population (7.82%) and the group of healthy subjects (10.71%). The median inducibility value was slightly higher among cancer patients with one or two M2 alleles than among patients homozygous for the wild-type allele (P = 0.09). However, the percentage of individuals possessing at least one mutated allele was not significantly higher among hyperinducible patients (37.5%) than among non-hyperinducible patients (16.0%). No significant correlation could be found between M2 allele and lung cancer or between M2 allele and CYplAZ inducibility; the only positive correlation found was between CYPlAZ hyperinduc- ibility and lung cancer incidence. Our observations do not support the view that the presence of the M2 allele at the MspI site of the CYPZAZ gene constitutes a significant lung cancer risk in Caucasians.