Reference : Modelling of the Nonlinear End-Systolic Pressure-Volume Relation and Volume-at-Zero-P...
Scientific congresses and symposiums : Paper published in a book
Human health sciences : Cardiovascular & respiratory systems
Engineering, computing & technology : Multidisciplinary, general & others
http://hdl.handle.net/2268/185656
Modelling of the Nonlinear End-Systolic Pressure-Volume Relation and Volume-at-Zero-Pressure in Porcine Experiments
English
Davidson, Shaun M. [> >]
Kannangara, D. Oliver [> >]
Pretty, Christopher G. [> >]
Kamoi, Shun [> >]
Pironet, Antoine mailto [Université de Liège > Département d'astrophys., géophysique et océanographie (AGO) > Thermodynamique des phénomènes irréversibles >]
Desaive, Thomas mailto [Université de Liège > Département d'astrophys., géophysique et océanographie (AGO) > Thermodynamique des phénomènes irréversibles >]
Chase, J. Geoffrey [> >]
Aug-2015
Proceedings of the 37th International Conference of the IEEE Engineering in Medicine and Biology Society
Yes
No
International
37th International Conference of the IEEE Engineering in Medicine and Biology Society
du 25 au 29 août 2015
IEEE Engineering in Medicine and Biology Society
Milan
Italie
[en] The End-Systolic Pressure-Volume Relation (ESPVR) is generally modelled as a linear relationship between P and V as cardiac reflexes, such as the baroreflex, are typically suppressed in experiments. However, ESPVR has been observed to behave in a curvilinear fashion when cardiac reflexes are not supressed, suggesting the curvilinear function may be more clinically appropriate. Data was gathered from 41 vena cava occlusion manoeuvres performed experimentally at a variety of PEEPs across 6 porcine specimens, and ESPVR determined for each pig. An exponential model of ESPVR was found to provide a higher correlation coefficient than a linear model in 6 out of 7 cases, and a lower Akaike Information Criterion (AIC) value in all cases. Further, the exponential ESPVR provided positive V0 values in a physiological range in6 out of 7 cases analysed, while the linear ESPVR produced positive V0 values in only 3 out of 7 cases, suggesting linear extrapolation of ESPVR to determine V0 may be flawed.
Researchers ; Professionals
http://hdl.handle.net/2268/185656

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