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Homocysteine et risque cardio-vasculaire
Lutteri, Laurence; Chapelle, Jean-Paul; Gielen, Jean-Louis
1999In Revue Médicale de Liège, 54 (6), p. 541-7
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Abstract :
[en] Homocystinuria is an uncommon genetic disease characterized by a marked increase of serum homocysteine (HCY), an intermediate of methionine metabolism. In patients with homocystinuria, hyperhomocysteinemia promotes the development of atherosclerotic lesions and is responsible for premature coronary artery disease. Recently, several studies have also demonstrated that moderate hyperhomocysteinemia--not necessarily linked to an inborn metabolic defect--may also be considered as an independant risk factor for cardiovascular disease. The main mechanisms of HCY atherogenic action are thought to be LDL oxydation, inhibition of vascular endothelium growth combined with stimulation of smooth muscular cells proliferation, and interference with the coagulation and fibrinolytic systems. Cofactors of key enzymes in HCY metabolism, folic acid, vitamin B12 and vitamin B6, may be given, alone or in combination, for the treatment of hyperhomocysteinemia. Homocysteinemia can be assessed by basal plasma HCY concentration and/or by HCY levels measured after a methionine loading test. Mainly measured till now in specialized laboratories using rather complex techniques (HPLC, GCMS, amino acid analyser ...), HCY determination is today spreading widely owing to the development of automated immunoassays.
Disciplines :
Laboratory medicine & medical technology
Cardiovascular & respiratory systems
Author, co-author :
Lutteri, Laurence ;  Centre Hospitalier Universitaire de Liège - CHU > Chimie médicale
Chapelle, Jean-Paul ;  Université de Liège - ULiège > Département de pharmacie > Chimie médicale
Gielen, Jean-Louis ;  Centre Hospitalier Universitaire de Liège - CHU > Chirurgie maxillo-faciale et plastique
Language :
French
Title :
Homocysteine et risque cardio-vasculaire
Alternative titles :
[en] Homocysteine and Cardiovascular Risk
Publication date :
June 1999
Journal title :
Revue Médicale de Liège
ISSN :
0370-629X
eISSN :
2566-1566
Publisher :
Université de Liège. Revue Médicale de Liège, Liège, Belgium
Volume :
54
Issue :
6
Pages :
541-7
Peer reviewed :
Peer reviewed
Available on ORBi :
since 28 January 2010

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