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Influence of circadian rhythm and PER3 genotype on executive discriminative ability under sleep deprivation during a constant routine
Jaspar, Mathieu; Meyer, Christelle; Muto, Vincenzo et al.
201317th EURON PhD Days
 

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Abstract :
[en] Maintaining optimal performance during a working memory task requires not only to detect target items but also to discard fillers. Following signal detection theory, the ability to discriminate target from non-target stimuli is estimated by d prime (d'). Here we assessed whether d' was modulated by the oscillating circadian signal during a 42-hour constant routine while participants performed 13 sessions of auditory 3-back task. We also tested whether the individual vulnerability to sleep loss predicted by the PERIOD3 gene polymorphism would influence this cognitive modulation imposed by sleep/wake regulation. From a sample of about 400 screened volunteers, thirty-five healthy young volunteers (age 19-26; 17 females) were recruited based on the PER3 polymorphism (twelve 5/5 and twenty-three 4/4 homozygotes). A linear mixed model tested on d’ the effect of circadian rhythmicity (based on melatonin level) and PER3 polymorphism. Given that 3back sessions were not administered at equidistant points, we used ranges to center each individual performance on dim light melatonin onset (DLMO). Analyses on d’ showed an effect of circadian oscillation (F(12,302) = 16.05, p< 0.0001), but also an interaction between gene and circadian oscillation (F(12,302)=1,88, p = 0.0362). This interaction was mainly characterized by a worst d’ in PER35/5subjects in the range covering a period between 21 and 23 hours after the DLMO (W=47; p = 0.0426). These results showed that circadian rhythm influence the discriminative ability under constant routine condition. Interestingly, we observed a better performance in PER34/4in the phase preceding the DLMO, but only in situation of high sleep pressure. Those results show that discriminative ability is differently affect by sleep homeostasis in PER3 polymorphism at the same circadian phase. We interpret this as a bigger vulnerability to sleep loss in PER35/5individuals in the period just before the wake maintenance zone.
Disciplines :
Life sciences: Multidisciplinary, general & others
Theoretical & cognitive psychology
Author, co-author :
Jaspar, Mathieu ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Meyer, Christelle ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Muto, Vincenzo  ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Shaffii-LeBourdiec, Anahita;  Université de Liège - ULiège > Centre de recherches du cyclotron
Chellappa, Sarah Laxhmi ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Vandewalle, Gilles  ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Collette, Fabienne  ;  Université de Liège - ULiège > Département de Psychologie : cognition et comportement > Neuropsychologie
Archer, Simon;  University of Surrey > Surrey Sleep Research Centre
Dijk, Derk-Jan;  University of Surrey > Surrey Sleep Research Centre
Maquet, Pierre  ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Language :
English
Title :
Influence of circadian rhythm and PER3 genotype on executive discriminative ability under sleep deprivation during a constant routine
Publication date :
12 August 2013
Event name :
17th EURON PhD Days
Event date :
du 12 septembre 2013 au 13 septembre 2013
Available on ORBi :
since 22 January 2015

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