Reference : Predicting the extent and location of coronary artery disease in acute myocardial inf...
Scientific journals : Article
Human health sciences : Cardiovascular & respiratory systems
Predicting the extent and location of coronary artery disease in acute myocardial infarction by echocardiography during dobutamine infusion.
BERTHE, Christian mailto [Centre Hospitalier Universitaire de Liège - CHU > > Cardiologie >]
Pierard, Luc mailto [Université de Liège - ULiège > Département des sciences cliniques > Cardiologie - Pathologie spéciale et réhabilitation >]
Hiernaux, M. [> >]
TROTTEUR, Geneviève mailto [Centre Hospitalier Universitaire de Liège - CHU > > Radiodiagnostic >]
Lempereur, P. [> >]
Carlier, J [> >]
Kulbertus, Henri mailto [Université de Liège - ULiège > > Relations académiques et scientifiques (Médecine) >]
American Journal of Cardiology
Yes (verified by ORBi)
[en] Adult ; Aged ; Coronary Disease/diagnosis ; Dobutamine/diagnostic use ; Echocardiography ; Electrocardiography ; Exercise Test ; Female ; Humans ; Male ; Middle Aged ; Myocardial Infarction/complications
[en] The feasibility, safety and usefulness of 2-dimensional echocardiography (2-D echo) during dobutamine infusion for identifying patients with multivessel coronary artery disease (CAD) after acute myocardial infarction (AMI) were evaluated in 30 patients 5 to 10 days after AMI. Patients underwent 2-D echo under basal conditions and during dobutamine infusion at each dose from 5 to a maximum of 40 micrograms/kg/min, limited multilead submaximal bicycle exercise testing and coronary and left ventricular angiography. Echocardiograms were analyzed independently by 2 observers. The test response was considered positive if abnormal wall motion and reduced myocardial thickening were observed during dobutamine infusion in vascular distributions other than the area of infarction identified during basal conditions. Exercise testing was considered positive when more than 1 mm of ST depression occurred 80 ms after the J point. Dobutamine stress testing was well tolerated; no complications and no significant arrhythmia were observed. Echocardiographic recordings were adequate in all patients during the entire test; the concordance in interpretation between the 2 observers was perfect for the prediction and location of ischemic segments during dobutamine infusion. In 15 of 17 patients without multivessel CAD, no asynergy was observed outside the infarct zone during dobutamine infusion (specificity 88%). In 11 of 13 patients with multivessel CAD, new wall motion abnormalities were identified in the segments corresponding to the arterial lesions diagnosed by angiography (sensitivity 85%).(ABSTRACT TRUNCATED AT 250 WORDS)

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