[en] In healthy adults cerebral blood flow is autoregulated and kept constant over a wide range of mean arterial blood pressures (MAP) between 60 and 150 mmHg. In 27 stable infants with different conceptional ages ranging from 33 to 50 weeks, Doppler measurements of mean flow velocity at the anterior cerebral artery have been recorded simultaneously with mean arterial blood pressures (MAP) during a period of 6 h. The range of autoregulation and its upper limit could thus be determined. The upper limit was found to increase with advancing age. In the infants with conceptional ages between 33 and 35 weeks, the upper limit of autoregulation varied between 45 and 60 mmHg, while the upper limit shifted to a MAP of 100 mmHg at 47 weeks conceptional age. A significant positive linear relationship existed between the upper limit of autoregulation and conceptional age.
Disciplines :
Neurology Pediatrics
Author, co-author :
RAMAEKERS, Vincent ; Developmental Neurology Research Unit, Department of Paediatrics and Neonatal Medicine, University Hospital Gasthuisberg, B-3000 Leuven, Belgium
Casaer, P.; Developmental Neurology Research Unit, Department of Paediatrics and Neonatal Medicine, University Hospital Gasthuisberg, B-3000 Leuven, Belgium
Daniels, H.; Developmental Neurology Research Unit, Department of Paediatrics and Neonatal Medicine, University Hospital Gasthuisberg, B-3000 Leuven, Belgium
Marchal, G.; tment of Radiology, Katholieke Universiteit Leuven, University Hospital Gasthuisberg, B-3000 Leuven, Belgium
Language :
English
Title :
Upper limits of brain blood flow autoregulation in stable infants of various conceptional age.
Batton, Hellman, Hernandez (1986) Regional cerebral blood flow, cerebral blood flow velocity, and pulsatility index in newborn dogs. Pediatr. Res. 17:908.
Casaer, Devlieger, Willekens (1980) Recording of upper and lower thoracic and abdominal respiratory movements in pre-term neonates. Acta Paediatr. Belg. 33:253-260.
Casaer, Devlieger (1984) The behavioural state in human perinatal life. J. Dev. Physiol. 6:187-194.
Guyton (1971) Regulation of acid-base balance. Textbook of Medical Physiology, A.C. Guyton, B. Saunders, Chapter 37; .
Greisen, Johansen, Ellison (1984) Cerebral blood flow in the newborn infant: Comparison of Doppler Ultrasound and 133 Xenon clearance. J. Pediatr. 104:411-418.
Hansen, Stonestreet, Rosenkrantz (1983) Validity of Doppler measurements of anterior cerebral artery blood flow velocity: correlation with brain blood flow in piglets. Pediatrics 72:526-531.
Haruda, Blanc (1981) The structure of intracerebral arteries in premature infants and the autoregulation of cerebral blood flow. Ann. Neurol. 10:303.
Kimble, Darnall, Yelderman (1981) An automated oscillometric technique for estimating mean arterial pressure in critically ill newborns. Anesthesiology 54:423-425.
Lassen (1959) Cerebral blood flow and oxygen consumption in man. Physiol. Rev. 39:183-239.
Perlman, Herscovitch, Corriveau (1985) The relationship of cerebral blood flow velocity, determined by Doppler, to regional cerebral blood flow, determined by positron emission tomography. Pediatr. Res. 19:357A.
Prechtl, O'Brien (1982) Behavioural states of the fullterm newborn. The emergence of a concept , P. Stratton, Psychobiology of the Human Newborn, John Willey and Sons Ltd, New York; 53-73.
Ramaekers, Casaer, Daniels (1989) The influence of behavioural states on cerebral blood flow velocity patterns in stable preterm infants. Early Hum. Dev. 20:229-246.
Siegel Nonparametric Statistics for the Behavioral Sciences, McGraw-Hill International Editions, New York; 1956.
Toole, Patel Cerebrovascular Disorders, McGraw-Hill, New York; 1974.
Volpe (1987) Specialized studies in the neurological evaluation. Neurology of the Newborn, J.J. Volpe, W.B. Saunders; .
Zwiebel (1986) Hemodynamic considerations in Peripheral and Cerebrovascular Disease. Introduction to Vascular Ultrasonography , Grune and Stratton; 17-19.
