[en] In healthy adults cerebral blood flow is autoregulated and kept constant over a wide range of mean arterial blood pressures (MAP) between 60 and 150 mmHg. In 27 stable infants with different conceptional ages ranging from 33 to 50 weeks, Doppler measurements of mean flow velocity at the anterior cerebral artery have been recorded simultaneously with mean arterial blood pressures (MAP) during a period of 6 h. The range of autoregulation and its upper limit could thus be determined. The upper limit was found to increase with advancing age. In the infants with conceptional ages between 33 and 35 weeks, the upper limit of autoregulation varied between 45 and 60 mmHg, while the upper limit shifted to a MAP of 100 mmHg at 47 weeks conceptional age. A significant positive linear relationship existed between the upper limit of autoregulation and conceptional age.
Disciplines :
Neurology Pediatrics
Author, co-author :
RAMAEKERS, Vincent ; Developmental Neurology Research Unit, Department of Paediatrics and Neonatal Medicine, University Hospital Gasthuisberg, B-3000 Leuven, Belgium
Casaer, P.; Developmental Neurology Research Unit, Department of Paediatrics and Neonatal Medicine, University Hospital Gasthuisberg, B-3000 Leuven, Belgium
Daniels, H.; Developmental Neurology Research Unit, Department of Paediatrics and Neonatal Medicine, University Hospital Gasthuisberg, B-3000 Leuven, Belgium
Marchal, G.; tment of Radiology, Katholieke Universiteit Leuven, University Hospital Gasthuisberg, B-3000 Leuven, Belgium
Language :
English
Title :
Upper limits of brain blood flow autoregulation in stable infants of various conceptional age.
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