Reference : Histamine plasmatique et bronchospasme d'effort.
Scientific journals : Article
Human health sciences : Cardiovascular & respiratory systems
Histamine plasmatique et bronchospasme d'effort.
[en] Plasma histamine and exercise-induced bronchospasm
Bury, Thierry mailto [Université de Liège - ULiège > Département des sciences de la motricité > Physiologie humaine et physiologie de l'effort physique]
PIRNAY, Freddy mailto [Centre Hospitalier Universitaire de Liège - CHU > > Pneumologie-Allergologie >]
CORHAY, Jean-Louis mailto [Centre Hospitalier Universitaire de Liège - CHU > > Pneumologie-Allergologie]
Bartsch, Pierre mailto [Université de Liège - ULiège > Services généraux (Faculté de médecine) > Relations académiques et scientifiques (Médecine)]
Radermecker, Maurice mailto [Université de Liège - ULiège > > Relations académiques et scientifiques (Médecine) >]
Revue des Maladies Respiratoires
Elsevier Masson
Yes (verified by ORBi)
[en] Adolescent ; Adult ; Asthma, Exercise-Induced/blood/etiology/immunology ; Epinephrine/blood ; Exercise Test ; Histamine/blood ; Humans ; Mast Cells/immunology ; Maximal Expiratory Flow Rate
[en] The pathogenesis of bronchospasm of effort is not yet elucidated and it is probable that is determined by multiple factors. In this study we have tested the role of mastocytes in taking as an index of their activation the fluctuation of plasma histamine levels during repeated exercise tests. We will show that asthmatic subjects who develop bronchospasm on effort have a significant rise (times 3) in their level of serum histamine whilst normal subjects don't show much change. Furthermore in a repeated effort test we have observed a strict parallelism between the occurrence of bronchospasm of effort and a rise in plasma histamine levels. These different observations enable us to consider that the activation of mastocytes and the liberation of mediators which follow play an important role in the pathogenesis of bronchospasm of effort.

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