Reference : Neurophysins as markers of vasopressin and oxytocin release. A study in carcinoma of ...
Scientific journals : Article
Human health sciences : Cardiovascular & respiratory systems
http://hdl.handle.net/2268/166513
Neurophysins as markers of vasopressin and oxytocin release. A study in carcinoma of the lung.
English
Legros, Jean-Jacques mailto [Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques]
Geenen, Vincent mailto [Université de Liège - ULiège > > Centre d'immunologie]
Carvelli, T [> > > >]
Martens, Henri mailto [Université de Liège - ULiège > > Centre d'immunologie]
Andre, Marie [> > > >]
CORHAY, Jean-Louis mailto [Centre Hospitalier Universitaire de Liège - CHU > > Pneumologie-Allergologie]
Radermecker, Maurice mailto [Université de Liège - ULiège]
Zangerlé, Pierre-François [Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques]
Sassolas, G [> > > >]
Gharib, C [> > > >]
1990
Hormone Research
S. Karger
34
3-4
151-5
Yes (verified by ORBi)
International
0301-0163
1423-0046
Basel
Switzerland
[en] Carcinoma, Small Cell/metabolism ; Carcinoma, Squamous Cell/metabolism ; Humans ; Inappropriate ADH Syndrome/diagnosis ; Lung Neoplasms/metabolism ; Neurophysins/blood ; Osmolar Concentration ; Oxytocin/secretion ; Tumor Markers, Biological ; Vasopressins/secretion
[en] Vasopressin-neurophysin (hNpI), oxytocin-neurophysin (hNpII) and blood osmolality were assayed before any treatment in basal conditions in 35 patients suffering from lung carcinoma (20 oat cell, 6 undifferentiated and 9 well-differentiated epidermoid cell carcinomas). Plasma vasopressin (antidiuretic hormone, ADH) was also assayed in 7 of the 20 patients suffering from oat cell carcinoma. We found a close correlation (r = 0.98) between plasma ADH and hNpI levels in the 7 patients. Further, hNpI was elevated in 13 out of the 20 oat cell carcinoma patients and in none of the epidermoid-cell carcinoma group; however, searching for an abnormality of ADH secretion as reflected by a detectable plasma hNpI level together with subnormal plasma osmolality revealed 2 additional positive results in the oat cell carcinoma group, and 2 out of the 6 in the undifferentiated-cell carcinoma group. hNpII was increased together with an increase in hNpI in 6 oat cell carcinoma patients; it was specifically increased without hNpI increment in 2 additional oat cell carcinoma patients and in 2 patients of the undifferentiated-cell carcinoma group (different from the 2 positive for the hNpI-osmolality ratio). hNpI and hNpII were normal in the majority of undifferentiated and all of the differentiated epidermoid-cell carcinoma group. Hence, our results show that simultaneous measurements of hNpI, hNpII, and blood osmolality could detect abnormalities in 17 out of 20 oat cell carcinoma patients, in 4 of the 9 undifferentiated-cell carcinoma patients, but in none of the differentiated epidermoid-cell carcinoma patients, suggesting that the neurophysin assay can be used for the early detection of oat cell- and possibly other neuroendocrine-derived carcinomas.
http://hdl.handle.net/2268/166513

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