Reference : Nonfibrous mineralogical analysis of bronchoalveolar lavage fluid from blast-furnace ...
Scientific journals : Article
Human health sciences : Cardiovascular & respiratory systems
Nonfibrous mineralogical analysis of bronchoalveolar lavage fluid from blast-furnace workers.
CORHAY, Jean-Louis mailto [Centre Hospitalier Universitaire de Liège - CHU > > Pneumologie-Allergologie]
Bury, Thierry mailto [Université de Liège - ULiège > Département des sciences de la motricité > Physiologie humaine et physiologie de l'effort physique]
Delavignette, Jean-Paul [Université de Liège - ULiège > Département des sciences de la santé publique > Santé au travail et éducation pour la santé (STES)]
Baharloo, F [> > > >]
Radermecker, Maurice mailto [Université de Liège - ULiège]
Hereng, P [> > > >]
Fransolet, André-Mathieu mailto [Université de Liège - ULiège > Département de géologie > Minéralogie et cristallochimie]
Weber, Georges mailto [Université de Liège - ULiège > > Centre européen en archéométrie]
Roelandts, I [> > > >]
Archives of Environmental Health
Heldref Publications
Yes (verified by ORBi)
[en] Adult ; Bronchoalveolar Lavage Fluid/chemistry ; Female ; Humans ; Male ; Metallurgy ; Metals/analysis ; Microscopy, Electron ; Middle Aged ; Minerals/analysis ; Occupational Exposure ; Pulmonary Alveoli/chemistry ; Smoking ; Spectrometry, X-Ray Emission ; Steel
[en] Steelworkers are exposed to many pollutants, and they are at risk for developing lung cancer. We demonstrated previously that steelworkers may be subject to an occult exposure to amphiboles in the plant environment. In the current study, we further analyzed bronchoalveolar lavage fluid of steelworkers by measuring intramacrophagic trace-metal content and nonfibrous mineral particles, using the particle-induced x-ray emission method and electron microscopy, respectively. Forty-seven blast-furnace workers and 45 healthy white-collar workers volunteered for this study. Significantly increased levels of iron, titanium, zinc, and bromine were found in the steelworkers, and levels of lead, chromium, arsenic, and strontium tended to increase in the macrophages and bronchoalveolar lavage fluid of the steelworkers. Nonfibrous particles, including illite, kaolinite, talc, chlorite, amorphous silica, quartz, iron (compounds), and titanium hydroxide, were found in both groups, but the particle number per ml bronchoalveolar lavage fluid (particularly iron hydroxides and silicates) was more pronounced in blast-furnace workers. These elements and particles may act synergistically with other occupational carcinogens and cigarette smoke, the result of which may be an increased incidence of lung cancer in the ironsteel industry.

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