Reference : Two years treatment with almitrine bismesylate in patients with hypoxic chronic obstr...
Scientific journals : Article
Human health sciences : Cardiovascular & respiratory systems
http://hdl.handle.net/2268/166286
Two years treatment with almitrine bismesylate in patients with hypoxic chronic obstructive airways disease.
English
Bardsley, P. A. [> >]
Howard, P. [> >]
DeBacker, W. [> >]
Vermeire, P. [> >]
Mairesse, M. [> >]
Ledent, C. [> >]
Radermecker, Maurice mailto [Université de Liège - ULiège > > Relations académiques et scientifiques (Médecine) >]
Bury, Thierry mailto [Université de Liège - ULiège > Département des sciences de la motricité > Physiologie humaine et physiologie de l'effort physique >]
Ansquer, J. [> >]
1991
European Respiratory Journal
4
3
308-10
Yes (verified by ORBi)
International
0903-1936
DENMARK
[en] Almitrine/administration & dosage/adverse effects/therapeutic use ; Anoxia/blood/drug therapy ; Carbon Dioxide/blood ; Double-Blind Method ; Female ; Humans ; Lung Diseases, Obstructive/drug therapy/mortality ; Male ; Middle Aged ; Oxygen/blood
[en] Eighty nine patients with hypoxic chronic obstructive airways disease (COAD) were enrolled into the 1 year Vectarion International Multicentre Study-VIMS in 4 centres, Sheffield (UK), and Antwerp, Liege and Namur (Belgium). At the end of the year the remainder were invited to continue taking placebo or almitrine bismesylate (100-200 mg daily) in the same double blind manner for a further 12 months. In the almitrine treated patients mean arterial oxygen tension (Pao2) at the end of the treatment period improved from 7.5 (0.5) kPa to 8.2 (1.3) kPa (p less than 0.01) and arterial carbon dioxide tension (Paco2) fell from 6.1 (0.8) kPa to 5.8 (0.9) kPa (p less than 0.01). Forced expiratory volume in one second (FEV1), forced vital capacity (FVC) and measurements of breathlessness were unchanged. In the placebo treated group changes in the above variables were not significant. Twenty nine patients withdrew from the almitrine group with seven deaths and six cases of peripheral neuropathy, and 22 patients withdrew from the placebo group with six deaths and two cases of peripheral neuropathy. Death rates between the groups were not significantly different. In conclusion, 2 yrs of almitrine treatment (100-200 mg daily) leads to a persistent slight improvement in PaO2 and PaCO2 but no benefit in survival was demonstrated. Patients in this study had a high incidence of drug related side-effects. Lower dose schedules should be investigated.
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/166286

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