Organization and activation of behavior in quail: role of testosterone metabolism.

Balthazart, Jacques; Schumacher, M.

doi:10.1002/jez.1402320328

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Organization and activation of behavior in quail: role of testosterone metabolism.

Balthazart, Jacques; Schumacher, M.

1984 • In Journal of Experimental Zoology, 232 (3), p. 595-604

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https://hdl.handle.net/2268/162371

DOI
10.1002/jez.1402320328

PubMed
6394700

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Keywords :

Animals; Coturnix/physiology; Dihydrotestosterone/biosynthesis; Estradiol/biosynthesis; Female; Hypothalamus/metabolism; Male; Quail/physiology; Sex Differentiation; Sexual Behavior, Animal/physiology; Sexual Maturation; Testosterone/metabolism

Abstract :

[en] In quail, the hypothalamus enzymatically transforms testosterone (T) into estradiol (E2), 5 alpha-dihydrotestosterone (5 alpha-DHT), and 5 beta-dihydrotestosterone (5 beta-DHT). During the embryonic life, the 5 beta-reductase activity is very high, which probably protects the brain of males from being behaviorally demasculinized by their endogenous T. 5 beta androstanes are inactive androgens. The decrease of 5 beta reductase with age during sexual maturation corresponds to a potentiation of the effects of T as shown by experiments that compared the effects of T and 5 alpha-DHT in adult and young quail. T metabolism is also involved in the activation of male behavior in the adult. T aromatization is probably essential for behavioral activation, but nonaromatizable androgens such as methyltrienolone, and to some extent 5 alpha-DHT, can also stimulate sexual behavior in castrates. These enzymatic activities show a clear neuroanatomical localization and are sexually dimorphic. Males produce more active metabolites (E2, 5 alpha-DHT) than females, which could explain the male's greater sensitivity to T treatments. It thus appears that T metabolism is involved in the differentiation and activation of behavior in quail.

Disciplines :

Zoology
Neurosciences & behavior

Author, co-author :

Balthazart, Jacques ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biologie de la différenciation sexuelle du cerveau

Schumacher, M.

Language :

English

Title :

Organization and activation of behavior in quail: role of testosterone metabolism.

Publication date :

1984

Journal title :

Journal of Experimental Zoology

ISSN :

0022-104X

eISSN :

1097-010X

Publisher :

John Wiley & Sons, Hoboken, United States - New Jersey

Volume :

232

Issue :

Pages :

595-604

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 29 January 2014

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Bibliography

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