[en] VO2 max, maximum oxygen uptake, has been measured in 4 normal young men, before and after beta-adrenergic blockade (0.5 to 5 mg Pindolol by mouth). Pindolol induces bradycardia and reduces VO2 max. A statistically significant positive correlation appears between posology of Pindolol and bradycardia, this posology and reduction of VO2 max, and finally between bradycardia and reduction of VO2 max. These correlations indicate that the reduction of VO2 max is best explained by a circulatory limitation of oxygen supply to active muscles.
Scheen, André ; Université de Liège - ULiège > Département des sciences cliniques > Diabétologie, nutrition et maladie métaboliques - Médecine interne générale
Juchmes, J.
Lennes, G.
Lecomte, Jean; Université de Liège - ULiège
Language :
French
Title :
Diminution de la consommation maximum d'oxygene apres blocage des recepteurs beta-andrenergiques
Alternative titles :
[fr] Decrease in maximum consumption of oxygen after blockage of beta-andrenergic receptors
Publication date :
1976
Journal title :
Archives Internationales de Physiologie et de Biochimie