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Article (Scientific journals)
Cardiovascular effects of intravenous tolmesoxide in hypertensive patients.
Scheen, André; Luyckx, A. S.; De Graeve, Jean
1981In Archives Internationales de Pharmacodynamie et de Thérapie, 251 (2), p. 322-34
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Keywords :
Adult; Antihypertensive Agents/pharmacology; Blood Glucose/metabolism; Diazoxide/pharmacology; Female; Glucagon/blood; Hemodynamics/drug effects; Humans; Hypertension/physiopathology; Insulin/blood; Male; Middle Aged; Sulfoxides/pharmacology; Toluene/analogs & derivatives/pharmacology
Abstract :
[en] Tolmesoxide, a potent vasodilating compound, was infused intravenously (0.5 to 3.5 mg/kg b.w., rate of infusion: 2.5 to 10.0 mg/min during 7--25 min, 2 or 3 successive infusions separated by a 30 min rest period) in 7 hypertensive patients. An abrupt fall in blood pressure and heart rate occurred in 4 patients whereas 2 patients exhibited almost no hemodynamic response. The remaining case suffering from renovascular hypertension responded with a progressive dose-dependent decrease in blood pressure. No obvious correlation could be demonstrated between the drug plasma levels (ranging between 1.0 and 11.1 microgram/ml) and the hemodynamic effects among the 7 patients studied.
Disciplines :
Cardiovascular & respiratory systems
Endocrinology, metabolism & nutrition
Author, co-author :
Scheen, André  ;  Université de Liège - ULiège > Département des sciences cliniques > Diabétologie, nutrition et maladie métaboliques - Médecine interne générale
Luyckx, A. S.
De Graeve, Jean ;  Université de Liège - ULiège > Services généraux (Faculté de médecine) > Relations académiques et scientifiques (Médecine)
Language :
English
Title :
Cardiovascular effects of intravenous tolmesoxide in hypertensive patients.
Publication date :
1981
Journal title :
Archives Internationales de Pharmacodynamie et de Thérapie
ISSN :
0301-4533
Publisher :
Heymans Institute of Pharmacology, Gent, Belgium
Volume :
251
Issue :
2
Pages :
322-34
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 08 June 2009

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