No full text
Article (Scientific journals)
The intra-nasal administration of insulin induces significant hypoglycaemia and classical counterregulatory hormonal responses in normal man.
Paquot, Nicolas; Scheen, André; Franchimont, P. et al.
1988In Diabète et Métabolisme, 14 (1), p. 31-6
Peer Reviewed verified by ORBi
 

Files


Full Text
No document available.

Send to



Details



Keywords :
Administration, Intranasal; Adult; Blood Glucose/metabolism; C-Peptide/blood; Fatty Acids, Nonesterified/blood; Glucagon/blood; Growth Hormone/blood; Humans; Hydrocortisone/blood; Hypoglycemia/blood; Insulin/administration & dosage/blood/pharmacology; Kinetics; Reference Values
Abstract :
[en] The present study aimed at investigating the metabolic and hormonal consequences of intra-nasal administration of insulin in normal man. Lyophylisated regular porcine insulin (Insuline Ordinaire Organon) diluted with a non ionic detergent (Laureth-9 0,25%) was administered intra-nasally in 8 overnight fasted healthy volunteers using a calibrated aerosol delivery device (90 microliters = 9 U of insulin/spray) up to a total insulin dose close to 1 U/kg body weight. After intra-nasal insulin administration, plasma insulin levels rose from 5 +/- 1 to 38 +/- 10 mU/l (2p less than 0.01) at min 15, blood glucose concentrations decreased from 4.4 +/- 0.2 to 3.2 +/- 0.3 mmol/l (2p less than 0.01) at min 45, plasma C-peptide levels diminished from 327 +/- 31 to 174 +/- 28 mumol/l (2p less than 0.01) at min 60 and plasma free fatty acids concentrations fell from 336 +/- 109 to 130 +/- 31 mumol/l (2p less than 0.05) at min 30. The fall in blood glucose resulted in a prompt increase in plasma glucagon levels (from 78 +/- 28 to 150 +/- 24 ng/l at min 45; 2p less than 0.05) and in later rises in plasma growth hormone and cortisol concentrations. There was a close relationship between the individual maximal decreases in blood glucose levels and the individual maximal increases in plasma insulin (r = 0.81), glucagon (r = 0.88), cortisol (r = 0.87) and growth hormone (r = 0.76) concentrations.(ABSTRACT TRUNCATED AT 250 WORDS)
Disciplines :
Endocrinology, metabolism & nutrition
Author, co-author :
Paquot, Nicolas ;  Centre Hospitalier Universitaire de Liège - CHU > Diabétologie,nutrition, maladies métaboliques
Scheen, André  ;  Université de Liège - ULiège > Département des sciences cliniques > Diabétologie, nutrition et maladie métaboliques - Médecine interne générale
Franchimont, P.
Lefebvre, Pierre ;  Centre Hospitalier Universitaire de Liège - CHU > Diabétologie,nutrition, maladies métaboliques
Language :
English
Title :
The intra-nasal administration of insulin induces significant hypoglycaemia and classical counterregulatory hormonal responses in normal man.
Publication date :
1988
Journal title :
Diabète et Métabolisme
ISSN :
0338-1684
Publisher :
Masson, Paris, France
Volume :
14
Issue :
1
Pages :
31-6
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 08 June 2009

Statistics


Number of views
35 (1 by ULiège)
Number of downloads
0 (0 by ULiège)

Scopus citations®
 
28
Scopus citations®
without self-citations
26

Bibliography


Similar publications



Contact ORBi