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Article (Scientific journals)
Effects of ethinyl estradiol combined with desogestrel and cyproterone acetate on glucose tolerance and insulin response to an oral glucose load: a one-year randomized, prospective, comparative trial.
Jandrain, Bernard; Humblet, Dominique; Jaminet, C. B. et al.
1990In American Journal of Obstetrics and Gynecology, 163 (1 Pt 2), p. 378-81
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Keywords :
Adult; Blood Glucose/metabolism; C-Peptide/blood; Contraceptives, Oral, Combined/pharmacology; Cyproterone/analogs & derivatives/pharmacology; Cyproterone Acetate; Desogestrel; Ethinyl Estradiol/pharmacology; Female; Glucose Tolerance Test; Humans; Insulin/blood; Norpregnenes/pharmacology; Progesterone Congeners/pharmacology; Prospective Studies; Random Allocation; Reference Values; OT - Belgium; OT - Biology; OT - *Carbohydrate Metabolic Effects; OT - *Comparative Studies; OT - Contraception; OT - Contraceptive Agents; OT - Contraceptive Agents, Estrogen; OT - Contraceptive Agents, Female; OT - Contraceptive Methods; OT - *Cyproterone Acetate; OT - Developed Countries; OT - Endocrine System; OT - *Ethinyl Estradiol; OT - Europe; OT - Examinations And Diagnoses; OT - Family Planning; OT - Hormone Antagonists; OT - Hormones; OT - *Laboratory Examinations And Diagnoses; OT - Metabolic Effects; OT - Oral Contraceptives; OT - *Oral Contraceptives, Low-dose; OT - Physiology; OT - *Prospective Studies; OT - Research Methodology; OT - Studies; OT - Western Europe
Abstract :
[en] To investigate the effects of two slightly estrogen-dominant, monophasic, low-dose oral contraceptives on carbohydrate metabolism, 40 healthy young women were randomly allocated to receive either 30 micrograms of ethinyl estradiol + 150 micrograms of desogestrel, a 19-nortestosterone-derived progestin (Marvelon; n = 21) or 35 micrograms of ethinyl estradiol + 2 mg of cyproterone acetate, a 17-acetoxyprogesterone derivative (Diane-35; n = (19) for a prospective observation period of 1 year. At baseline, 6, and 12 months, blood glucose, plasma insulin, and plasma C-peptide levels were measured during an oral glucose tolerance test. Although the changes were absent (Marvelon) or minimal (Diane-35) at 6 months, both groups had a slight increase in blood glucose levels at 12 months; overall glucose tolerance remaining, however, within the normal range. Plasma insulin levels remained unchanged in the Diane-35-group, which suggested increased insulin resistance, but were significantly decreased in the Marvelon group despite significant rises in plasma C-peptide levels. Comparison of plasma C-peptide and insulin changes suggests enhanced pancreatic insulin secretion and increased hepatic insulin metabolism with both Marvelon and Diane-35.
Disciplines :
Reproductive medicine (gynecology, andrology, obstetrics)
Pharmacy, pharmacology & toxicology
Endocrinology, metabolism & nutrition
Author, co-author :
Jandrain, Bernard ;  Centre Hospitalier Universitaire de Liège - CHU > Diabétologie,nutrition, maladies métaboliques
Humblet, Dominique ;  Centre Hospitalier Universitaire de Liège - CHU > Ophtalmologie
Jaminet, C. B.
Scheen, André  ;  Université de Liège - ULiège > Département des sciences cliniques > Diabétologie, nutrition et maladie métaboliques - Médecine interne générale
Gaspard, Ulysse ;  Centre Hospitalier Universitaire de Liège - CHU > Gynécologie-Obstétrique
Lefebvre, Pierre ;  Centre Hospitalier Universitaire de Liège - CHU > Diabétologie,nutrition, maladies métaboliques
Language :
English
Title :
Effects of ethinyl estradiol combined with desogestrel and cyproterone acetate on glucose tolerance and insulin response to an oral glucose load: a one-year randomized, prospective, comparative trial.
Publication date :
1990
Journal title :
American Journal of Obstetrics and Gynecology
ISSN :
0002-9378
eISSN :
1097-6868
Publisher :
Mosby, St Louis, United States - Missouri
Volume :
163
Issue :
1 Pt 2
Pages :
378-81
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
PIP: TJ: AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY.
Available on ORBi :
since 05 June 2009

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