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From obesity to type 2 diabetes.
Scheen, André
1992In Acta Clinica Belgica. Supplementum, 14, p. 30-6
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Keywords :
Diabetes Mellitus/physiopathology; Diabetes Mellitus, Type 2/physiopathology; Gluconeogenesis; Glucose/metabolism; Humans; Insulin/secretion; Insulin Resistance/physiology; Lipolysis; Metabolic Clearance Rate; Obesity
Abstract :
[en] Obesity is a well-known risk factor for the development of non-insulin-dependent diabetes mellitus (NIDDM). Both insulin resistance and concomitant B-cell dysfunction are necessary for the development of NIDDM. Insulin resistance, probably genetically determined but worsened by obesity, appears to be the primary defect that leads to impaired glucose tolerance. However, B-cell dysfunction plays a critical role during progressive deterioration from mild impaired glucose tolerance to severe NIDDM.
Disciplines :
Endocrinology, metabolism & nutrition
Author, co-author :
Scheen, André  ;  Université de Liège - ULiège > Département des sciences cliniques > Diabétologie, nutrition et maladie métaboliques - Médecine interne générale
Language :
English
Title :
From obesity to type 2 diabetes.
Publication date :
1992
Journal title :
Acta Clinica Belgica. Supplementum
ISSN :
0567-7386
Publisher :
A. van Tilburg, Bruxelles, Belgium
Volume :
14
Pages :
30-6
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 05 June 2009

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