Reference : Reduction of the acute bioavailability of metformin by the alpha-glucosidase inhibito...
Scientific journals : Article
Human health sciences : Pharmacy, pharmacology & toxicology
Human health sciences : Endocrinology, metabolism & nutrition
http://hdl.handle.net/2268/14006
Reduction of the acute bioavailability of metformin by the alpha-glucosidase inhibitor acarbose in normal man.
English
Scheen, André mailto [Université de Liège - ULiège > Département des sciences cliniques > Diabétologie, nutrition et maladie métaboliques - Médecine interne générale >]
de Magalhaes, A. C. [> > > >]
Salvatore, T. [> > > >]
Lefebvre, Pierre [Centre Hospitalier Universitaire de Liège - CHU > > Diabétologie,nutrition, maladies métaboliques >]
1994
European Journal of Clinical Investigation
Blackwell Publishing
24 Suppl 3
50-4
Yes (verified by ORBi)
0014-2972
1365-2362
Oxford
United Kingdom
[en] Acarbose ; Adult ; Biological Availability ; Blood Glucose/drug effects/metabolism ; Cross-Over Studies ; Double-Blind Method ; Humans ; Hypoglycemic Agents/pharmacology ; Insulin/blood ; Male ; Metformin/blood/pharmacokinetics ; Reference Values ; Trisaccharides/pharmacology ; alpha-Glucosidases/antagonists & inhibitors
[en] In a double-blind cross-over study, we investigated a possible influence of the alpha-glucosidase inhibitor acarbose on the bioavailability of the biguanide compound metformin. Each of the six healthy young male volunteers was randomly allocated during two consecutive 7 day periods to either acarbose (days 1-3: 3 x 50 mg day-1; days 4-7: 3 x 100 mg day-1) or placebo. At day 7 and 14 of the study, the overnight-fasted subjects ingested 1000 mg metformin with the first bite of a standardized breakfast (500 kcal; 60 g carbohydrates) and together with either placebo or 100 mg acarbose. Acarbose significantly (P < 0.05) reduced the meal-induced increase in blood glucose and plasma insulin levels. Acarbose induced a significant (P < 0.05) reduction in early (90, 120, 180 min) serum levels, peak concentrations (Cmax: 1.22 +/- 0.14 vs. 1.87 +/- 0.60 mg l-1) and area under the curve of metformin (AUC 0-540 min: 423 +/- 55 vs. 652 +/- 55 mg min l-1), but did not diminish its 24 h urinary excretion. In conclusion, acarbose significantly reduces the acute bioavailability of metformin in normal subjects.
http://hdl.handle.net/2268/14006

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