Reference : Abnormal temporal patterns of glucose tolerance in obesity: relationship to sleep-rel...
Scientific journals : Article
Human health sciences : Endocrinology, metabolism & nutrition
http://hdl.handle.net/2268/13999
Abnormal temporal patterns of glucose tolerance in obesity: relationship to sleep-related growth hormone secretion and circadian cortisol rhythmicity.
English
Van Cauter, E. V. [> > > >]
Polonsky, K. S. [> > > >]
Blackman, J. D. [> > > >]
Roland, D. [> > > >]
Sturis, J. [> > > >]
Byrne, M. M. [> > > >]
Scheen, André mailto [Université de Liège - ULiège > Département des sciences cliniques > Diabétologie, nutrition et maladie métaboliques - Médecine interne générale >]
1994
Journal of Clinical Endocrinology and Metabolism
Endocrine Society
79
6
1797-805
Yes (verified by ORBi)
0021-972X
1945-7197
Chevy Chase
MD
[en] Adult ; Blood Glucose/metabolism ; C-Peptide/blood ; Circadian Rhythm ; Glucose Tolerance Test ; Growth Hormone/secretion ; Humans ; Hydrocortisone/blood ; Insulin/blood/secretion ; Kinetics ; Male ; Obesity/physiopathology ; Sleep/physiology ; Wakefulness
[en] To define the chronobiology of glucose tolerance and insulin secretion in obesity, nine obese men and nine lean men were studied during constant glucose infusion for 53 h, including 8 h of nocturnal sleep, 28 h of continuous wakefulness, and 8 h of daytime sleep. Blood samples were collected at 20-min intervals to assay glucose, insulin, C-peptide, cortisol, and GH. Sleep was polygraphically monitored. Abnormal temporal profiles of glucose regulation were observed during wakefulness and sleep in obese subjects. During daytime hours, the normal profile of glucose tolerance was reversed, as an improvement, rather than a deterioration, was observed from morning to late evening. This reversal of the daytime pattern appeared to be caused by a dual defect in glucose regulation during the previous night. Indeed, during early sleep, GH secretion was markedly reduced, and the nocturnal rises of glucose and insulin secretion were dampened. During late sleep, obese subjects failed to suppress insulin secretion and plasma glucose, resulting in high morning levels. Comparisons of metabolic and hormonal patterns during nocturnal and daytime sleep suggest that the failure to suppress insulin secretion in late sleep may reflect a relative insensitivity of the beta-cell to acute inhibitory effects of cortisol in addition to insulin resistance.
http://hdl.handle.net/2268/13999
10.1210/jc.79.6.1797

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