No full text
Article (Scientific journals)
Glucose metabolism in obese subjects: lessons from OGTT, IVGTT and clamp studies.
Scheen, André; Paquot, Nicolas; Letiexhe, Michel et al.
1995In International Journal of Obesity, 19 Suppl 3, p. 14-20
Peer Reviewed verified by ORBi
 

Files


Full Text
No document available.

Send to



Details



Keywords :
Blood Glucose/metabolism; Body Weight/physiology; Female; Glucose/metabolism; Glucose Clamp Technique; Glucose Tolerance Test; Humans; Hyperglycemia/metabolism/physiopathology; Hyperinsulinism/metabolism/physiopathology; Insulin Resistance/physiology; Obesity/blood/metabolism/physiopathology
Abstract :
[en] Impaired glucose tolerance and overt diabetes are more frequent in presence than in absence of obesity. In obese subjects, glucose tolerance can be maintained within the normal range by compensating for insulin resistance by peripheral hyperinsulinism, the latter resulting from both increased insulin secretion and reduced insulin clearance. Impaired glucose tolerance is observed when insulin resistance is associated to impaired first-phase insulin response, which results in a significant increase in plasma glucose levels and a late insulin hyperresponsiveness. Both hyperinsulinaemia and hyperglycaemia are then able to overcome peripheral insulin resistance and impaired glucose disposal. When a more marked defect in insulin secretion is present, hyperglycaemia progresses, probably due to an additional participation of impaired suppression of hepatic glucose output. Overt diabetes then occurs with persistent post-absorptive hyperglycaemia. All these abnormalities can be reversed after a marked weight loss and recovery of ideal body weight, arguing for acquired rather than inherited metabolic defects in presence of morbid obesity. If a sufficient weight reduction can not be obtained, pharmacological approaches may be considered to improve insulin resistance of obese subjects, especially those with impaired glucose tolerance or overt diabetes.
Disciplines :
Endocrinology, metabolism & nutrition
Author, co-author :
Scheen, André  ;  Université de Liège - ULiège > Département des sciences cliniques > Diabétologie, nutrition et maladie métaboliques - Médecine interne générale
Paquot, Nicolas ;  Centre Hospitalier Universitaire de Liège - CHU > Diabétologie,nutrition, maladies métaboliques
Letiexhe, Michel ;  Centre Hospitalier Universitaire de Liège - CHU > Diabétologie,nutrition, maladies métaboliques
Paolisso, G.
Castillo, M. J.
Lefebvre, Pierre ;  Centre Hospitalier Universitaire de Liège - CHU > Diabétologie,nutrition, maladies métaboliques
Language :
English
Title :
Glucose metabolism in obese subjects: lessons from OGTT, IVGTT and clamp studies.
Publication date :
1995
Journal title :
International Journal of Obesity
ISSN :
0307-0565
eISSN :
1476-5497
Publisher :
Nature Publishing Group, London, United Kingdom
Volume :
19 Suppl 3
Pages :
S14-20
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 05 June 2009

Statistics


Number of views
96 (3 by ULiège)
Number of downloads
0 (0 by ULiège)

Scopus citations®
 
44
Scopus citations®
without self-citations
23

Bibliography


Similar publications



Contact ORBi