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Molecular bases of the interaction between human prolactin and its membrane receptor: A ten year study
KINET, Sandrina; BERNICHTEIN, Sophie; LLOVERA, Marta et al.
2001In Recent research developments in endocrinology, 2, p. 1-23
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Keywords :
human prolactin; membrane receptor
Abstract :
[en] In this review, we make a chronologically overview of a project aimed at deciphering the molecular bases of the mechanism by which prolactin, a pituitary-secreted polypeptidic hormone, interacts with its membrane receptor, a member of the cytokine receptor superfamily. This study, based essentially on structural and mutational analysis of human prolactin, has identified two regions interacting with the receptor, named binding sites 1 and 2. We have also provided evidence that prolactin induces dimerization of its receptor through its two binding sites, and based on that mechanism of activation, we have engineered and characterized prolactin antagonists able to block the effect of the hormone by competition for receptor binding. Our study has also highlighted the importance of using well characterized bioassays to monitor such a structure-function study since the properties of a given hormone analog were shown to strongly differ depending on the bioassay used.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
KINET, Sandrina
BERNICHTEIN, Sophie;  INSERM Unit 344
LLOVERA, Marta;  INSERM Unit 344
KELLY, Paul A.;  INSERM Unit 344
Martial, Joseph ;  Université de Liège - ULiège > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire
GOFFIN, Vincent
Language :
English
Title :
Molecular bases of the interaction between human prolactin and its membrane receptor: A ten year study
Publication date :
2001
Journal title :
Recent research developments in endocrinology
Volume :
2
Pages :
1-23
Peer reviewed :
Peer reviewed
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since 04 June 2009

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