Reference : New dimensions in tumor immunology: what does 3D culture reveal?
Scientific journals : Article
Human health sciences : Oncology
http://hdl.handle.net/2268/137630
New dimensions in tumor immunology: what does 3D culture reveal?
English
Feder-Mengus, Chantal [> >]
Ghosh, Sourabh [> >]
Reschner, Anca [Université de Liège - ULiège > > Immunologie et vaccinologie >]
Martin, Ivan [> >]
Spagnoli, Giulio C. [> >]
2008
Trends in Molecular Medicine
14
8
333-40
Yes (verified by ORBi)
1471-4914
England
[en] Animals ; Cell Culture Techniques ; Humans ; Neoplasms/immunology/pathology ; Neoplastic Stem Cells/physiology ; Tumor Cells, Cultured ; Tumor Escape
[en] Experimental models indicate that tumor cells in suspension, unlike solid tumor fragments, might be unable to produce life-threatening cancer outgrowth when transferred to animal models, irrespective of the number of cells transferred, although they induce specific immune responses. Human tumor cells cultured in three dimensions display increased pro-angiogenic capacities and resistance to interferons, chemotherapeutic agents or irradiation, as compared with cells cultured in two-dimensional (2D) monolayers. Tumor cells cultured in three dimensions were also shown to be characterized by defective immune recognition by cytotoxic T lymphocytes (CTLs) specific for tumor-associated antigens (TAAs) and by a capacity to inhibit CTL proliferation and dendritic cell (DC) functions. Downregulation of human leukocyte antigen (HLA) or TAA expression and high production of lactic acid might play a role in the elicitation of these effects. Here, we propose that growth in 3D architectures might provide new insights into tumor immunology and could represent an integral missing component in pathophysiological tumor immune escape mechanisms.
http://hdl.handle.net/2268/137630
10.1016/j.molmed.2008.06.001

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